Gene Symbol | Fbxo5 |
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Entrez Gene | 67141 |
Alt Symbol | 2510044I10Rik, C85305, Emi1, Fbxo31 |
Species | Mouse |
Gene Type | protein-coding |
Description | F-box protein 5 |
Other Description | F-box only protein 5|early mitotic inhibitor 1|f-box only protein 31|fbxo5 |
Swissprots | Q7TSG3 |
Accessions | EDL03567 Q7TSG3 AK011820 BAB27861 AK135916 AK160201 BC053434 AAH53434 NM_025995 NP_080271 |
Function | Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000250|UniProtKB:Q9UKT4, ECO:0000269|PubMed:16809773}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle (By similarity). {ECO:0000250}. |
Top Pathways | Oocyte meiosis |
Emi1 CRISPR/Cas9 KO Plasmid (m) - sc-426405 from Santa Cruz Biotechnology
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Emi1 HDR Plasmid (m) - sc-426405-HDR from Santa Cruz Biotechnology
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Emi1 Double Nickase Plasmid (m) - sc-426405-NIC from Santa Cruz Biotechnology
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Emi1 Double Nickase Plasmid (m2) - sc-426405-NIC-2 from Santa Cruz Biotechnology
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Emi1 CRISPR Activation Plasmid (m) - sc-426405-ACT from Santa Cruz Biotechnology
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Emi1 CRISPR Activation Plasmid (m2) - sc-426405-ACT-2 from Santa Cruz Biotechnology
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Emi1 Lentiviral Activation Particles (m) - sc-426405-LAC from Santa Cruz Biotechnology
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Emi1 Lentiviral Activation Particles (m2) - sc-426405-LAC-2 from Santa Cruz Biotechnology
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Emi1 siRNA (m) - sc-44344 from Santa Cruz Biotechnology
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Emi1shRNA Plasmid (m)-SH - sc-44344-SH from Santa Cruz Biotechnology
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Emi1shRNA (m) Lentiviral Particles - sc-44344-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU094261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN31261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31261 from Sigma-Aldrich
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FBXO5 siRNA (Mouse) - CRM7022 from Cohesion Biosciences
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FBXO5 - MBS8209362 from MyBioSource
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shRNA set against Mouse FBXO5 (NM_025995.2) - SHH293397 from Creative biogene
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shRNA set against Mouse Fbxo5(NM_025995.2) - SHH053093 from Creative biogene
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Mouse FBXO5 siRNA - orb286498 from Biorbyt
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FBXO5 shRNA Plasmid (Mouse) - CHM7022 from Cohesion Biosciences
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FBXO5 miRNA 3'UTR clone - MiUTR1M-04631 from Creative biogene
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