Gene Symbol | Fbxo5 |
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Entrez Gene | 67141 |
Alt Symbol | 2510044I10Rik, C85305, Emi1, Fbxo31 |
Species | Mouse |
Gene Type | protein-coding |
Description | F-box protein 5 |
Other Description | F-box only protein 5|early mitotic inhibitor 1|f-box only protein 31|fbxo5 |
Swissprots | Q7TSG3 |
Accessions | EDL03567 Q7TSG3 AK011820 BAB27861 AK135916 AK160201 BC053434 AAH53434 NM_025995 NP_080271 |
Function | Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000250|UniProtKB:Q9UKT4, ECO:0000269|PubMed:16809773}. |
Subcellular Location | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration. In mitotic cells, localizes throughout the cell, particularly at the spindle (By similarity). {ECO:0000250}. |
Top Pathways | Oocyte meiosis |
Recombinant Mouse F-box only protein 5(Fbxo5) - CSB-YP766518MO CSB-EP766518MO CSB-BP766518MO CSB-MP766518MO from Cusabio
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Recombinant Mouse FBXO5 Protein - FBXO5-5759M from Creative Biomart
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F-box only protein 5 (Fbxo5), Recombinant Protein - MBS1390499 from MyBioSource
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