| Gene Symbol |
CASS4
|
| Entrez Gene |
57091
|
| Alt Symbol |
C20orf32, CAS4, HEFL, HEPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cas scaffolding protein family member 4
|
| Other Description |
HEF-like protein|HEF1-EFS-p130Cas-like protein|cas scaffolding protein family member 4
|
| Swissprots |
Q9NQ75 Q9BYL5 Q96K09 E1P5Z8 Q5QPD6
|
| Accessions |
EAW75541 EAW75542 EAW75543 EAW75544 EAW75545 EAW75546 EAW75547 Q9NQ75 AJ276678 CAC00655 AK027760 BAB55351 AK295613 BAG58496 AK308057 AK314653 BC027951 AAH27951 BX280195 DA584687 XM_006723831 XP_006723894 NM_001164114 NP_001157586 NM_001164115 NP_001157587 NM_001164116 NP_001157588 NM_020356 NP_065089
|
| Function |
Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18256281}. Cell junction, focal adhesion {ECO:0000269|PubMed:18256281}.
|
| Tissue Specificity |
Expressed abundantly in lung and spleen. Also highly expressed in ovarian and leukemia cell lines. {ECO:0000269|PubMed:18256281}.
|