| Gene Symbol |
WIPF1
|
| Entrez Gene |
7456
|
| Alt Symbol |
PRPL-2, WAS2, WASPIP, WIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WAS/WASL interacting protein family, member 1
|
| Other Description |
WAS/WASL-interacting protein family member 1|WASP-interacting protein|Wiskott-Aldrich syndrome protein interacting protein|protein PRPL-2
|
| Swissprots |
Q6MZU9 B8ZZM1 O43516 Q53TA9 Q9BU37 D3DPE4 Q9UNP1 Q15220
|
| Accessions |
AAY14708 EAX11129 EAX11130 EAX11131 EAX11132 EAX11133 EAX11134 EAX11135 O43516 AA599214 AA903457 AF031588 AAC03767 AF106062 AAD45972 AK097901 AK301271 BAG62833 AK304194 BAG65074 AL529597 AL832275 BC002914 AAH02914 BC045584 BC110288 AAI10289 BG820214 BM475558 BM542331 BQ016063 BQ441937 BX640870 CAE45928 DA674627 EU832147 ACE87497 EU832240 ACE86810 X86019 CAA60014 XM_011511780 XP_011510082 XM_011511781 XP_011510083 NM_001077269 NP_001070737 NM_003387 NP_003378
|
| Function |
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. {ECO:0000250, ECO:0000269|PubMed:10878810, ECO:0000269|PubMed:19910490, ECO:0000269|PubMed:9405671}.
|
| Subcellular Location |
Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000269|PubMed:19910490}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis. {ECO:0000269|PubMed:9405671}.
|