| Gene Symbol |
PARVB
|
| Entrez Gene |
29780
|
| Alt Symbol |
CGI-56
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
parvin, beta
|
| Other Description |
affixin|beta-parvin
|
| Swissprots |
Q96PN1 Q86X93 Q5TGJ5 B2R9X6 Q9NSP7 Q9UGT3 B0QYN1 Q9Y3L7 Q9HBI1 B0QYM8 Q9Y3L6 Q9Y368
|
| Accessions |
EAW73328 EAW73329 EAW73330 EAW73331 Q9HBI1 AB048276 BAB62077 AF151814 AAD34051 AF237769 AAG27171 AF303887 AAL08219 AK308443 AK309987 AK313957 BAG36673 AL159142 CAB76900 BC017461 BC039811 BC046103 AAH46103 BG743702 BP339885 CA308417 CB044150 XM_005261596 XP_005261653 NM_001003828 NP_001003828 NM_001243385 NP_001230314 NM_001243386 NP_001230315 NM_013327 NP_037459
|
| Function |
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
|
| Subcellular Location |
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
|
| Tissue Specificity |
Expressed predominantly in heart and skeletal muscle. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:11722847}.
|
| Top Pathways |
Focal adhesion
|
![Western Blot: PARVB Overexpression Lysate (Adult Normal) [NBL1-14121] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PARVB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19610_PARVB%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14121-img0002.jpg)