PARVB

Gene Symbol PARVB
Entrez Gene 29780
Alt Symbol CGI-56
Species Human
Gene Type protein-coding
Description parvin, beta
Other Description affixin|beta-parvin
Swissprots Q96PN1 Q86X93 Q5TGJ5 B2R9X6 Q9NSP7 Q9UGT3 B0QYN1 Q9Y3L7 Q9HBI1 B0QYM8 Q9Y3L6 Q9Y368
Accessions EAW73328 EAW73329 EAW73330 EAW73331 Q9HBI1 AB048276 BAB62077 AF151814 AAD34051 AF237769 AAG27171 AF303887 AAL08219 AK308443 AK309987 AK313957 BAG36673 AL159142 CAB76900 BC017461 BC039811 BC046103 AAH46103 BG743702 BP339885 CA308417 CB044150 XM_005261596 XP_005261653 NM_001003828 NP_001003828 NM_001243385 NP_001230314 NM_001243386 NP_001230315 NM_013327 NP_037459
Function Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:15005707, ECO:0000269|PubMed:15159419, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:18325335}.
Subcellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
Tissue Specificity Expressed predominantly in heart and skeletal muscle. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:11722847}.
Top Pathways Focal adhesion

Human PARVB full length protein - ab162234 from Abcam

Category Protein
Source Wheat germ
Species Human
ab162234 on a 12.5% SDS-PAGE stained with Coomassie Blue.

PARVB Antibody Blocking Peptide - LS-E16763 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PARVB Antibody Blocking Peptide - LS-E16764 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human PARVB Protein - H00029780-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

PARVB-Antibody-N-term-Blocking-peptide - BP11774a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

PARVB Blocking Peptide - 33R-3803 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PARVB Blocking Peptide - 33R-5302 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PARVB - H00029780-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

PARVB - H00029780-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

PARVB fusion protein - ag5760 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

PARVB fusion protein - Ag5993 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human Beta-parvin(PARVB) - CSB-YP875712HU CSB-EP875712HU CSB-BP875712HU CSB-MP875712HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

PARVB (transcript variant 2) - TP308490 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
PARVB

PARVB Peptide, Human - M34GP11328H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Beta-parvin (PARVB), Recombinant Protein - MBS1367692 from MyBioSource

Category Protein
Prices $1,130.00, $1,130.00, $1,360.00, $1,360.00, $1,795.00, $1,795.00, $2,260.00, $2,260.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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