Nampt

Gene Symbol	Nampt
Entrez Gene	297508
Alt Symbol	Pbef, Pbef1
Species	Rat
Gene Type	protein-coding
Description	nicotinamide phosphoribosyltransferase
Other Description	NAmPRTase|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1 homolog|visfatin
Swissprots	Q2VT47 Q80Z29
Accessions	EDM03273 Q80Z29 AB081730 BAC66022 AY831728 AAX49410 BC085681 AAH85681 NM_177928 NP_808789
Function	Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000250|UniProtKB:Q99KQ4}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
Tissue Specificity	Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung. {ECO:0000269|PubMed:12782293}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

PBEF/Visfatin/NAMPT Antibody - AF6384 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Visfatin antibody - 70R-12453 from Fitzgerald Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Nicotinamide Phosphoribosyltransferase Antibody - abx114108 from Abbexa Host Rabbit Clonality Polyclonal

Visfatin Antibody - abx100120 from Abbexa Host Rabbit Clonality Polyclonal

Visfatin / NAMPT antibody - PAB9554 from Acris Antibodies Prices $430.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Rabbit Anti-Visfatin Antibody - 168-11076 from RayBiotech Host Rabbit

Anti-Nampt (Visfatin/PBEF) - 23-10033 from ARP American Research Products Prices $129.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Visfatin (VF) - 20-2972 from ARP American Research Products Prices $329.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NAMPT polyclonal antibody - DPAB-DC1504 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Visfatin (VF), Polyclonal Antibody - MBS2005393 from MyBioSource Prices $135.00, $160.00, $230.00, $310.00, $480.00, $1,155.00 Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg Host Rabbit Clonality Polyclonal

Visfatin (VF), Polyclonal Antibody - MBS2016197 from MyBioSource Prices $145.00, $175.00, $265.00, $370.00, $575.00, $1,380.00 Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg Host Rabbit Clonality Polyclonal

Visfatin (VF), Polyclonal Antibody - MBS2007027 from MyBioSource Prices $140.00, $165.00, $250.00, $340.00, $530.00, $1,270.00 Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg Host Rabbit Clonality Polyclonal

Visfatin - ABA-121-02100 from Nordic BioSite Host Rabbit Clone polyclonal

NAMPT Antibody - CSB-PA015422GA01HU from Cusabio Host Rabbit

Nampt (Visfatin/PBEF) antibody - pab10050 from Covalab Host Rabbit Clonality Polyclonal

Monoclonal Antibody to Visfatin (VF) - MAA638Ra21 from Cloud-clone Host Mouse Clonality Monoclonal

Polyclonal Antibody to Visfatin (VF) - PAA638Ra01 from Cloud-clone Host Rabbit Clonality Polyclonal

Biotin-Linked Antibody to Visfatin (VF) - PAA638Ra71 from Cloud-clone Host Rabbit Clonality Polyclonal

FITC-Linked Antibody to Visfatin (VF) - PAA638Ra81 from Cloud-clone Host Rabbit Clonality Polyclonal

Visfatin Antibody - 5909-100 from Biovision Prices $245.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Visfatin, Polyclonal Antibody - MBS840607 from MyBioSource Prices $150.00, $290.00 Sizes 30 µg, 100 µg Host Rabbit Clonality Polyclonal

Visfatin, Monoclonal Antibody - MBS2025779 from MyBioSource Prices $140.00, $245.00, $330.00 Sizes 20 µg, 100 µg, 200 µg Host Mouse Clonality Monoclonal

Visfatin-Antibody - ABV11617 from Abgent, a WuXi AppTec company Prices $89.00, $245.00 Sizes 30 µg, 100 µg Host Rabbit Clonality Polyclonal

Nampt Antibody - 36-232 from ProSci Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Visfatin (VF) Monoclonal Antibody - CAU29282 from Biomatik Prices $81.00, $192.00, $269.00, $384.00 Sizes 10 μg, 50 μg, 100 μg, 200 μg Host Mouse Clonality Monoclonal

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