Nampt

Gene Symbol Nampt
Entrez Gene 297508
Alt Symbol Pbef, Pbef1
Species Rat
Gene Type protein-coding
Description nicotinamide phosphoribosyltransferase
Other Description NAmPRTase|pre-B-cell colony enhancing factor 1|pre-B-cell colony-enhancing factor 1 homolog|visfatin
Swissprots Q2VT47 Q80Z29
Accessions EDM03273 Q80Z29 AB081730 BAC66022 AY831728 AAX49410 BC085681 AAH85681 NM_177928 NP_808789
Function Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000250|UniProtKB:Q99KQ4}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12782293}. Cytoplasm {ECO:0000269|PubMed:12782293}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
Tissue Specificity Expressed in various tissues. At the highest level in liver and at the second highest in heart. The amount is higher in heart than in lung. {ECO:0000269|PubMed:12782293}.
Top Pathways Nicotinate and nicotinamide metabolism

CompoZr® Knockout ZFN Kit - CKOZFN57745 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND57745 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NAMPT siRNA (Rat) - CRR4517 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat NAMPT (NM_177928.3) - SHH349148 from Creative biogene

Category siRNA
Species Reactivities Rat

shRNA set against Rat Pbef1(NM_177928.3) - SHR090240 from Creative biogene

Category siRNA
Species Reactivities Rat

NAMPT shRNA Plasmid (Rat) - CHR4517 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat
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