DGKQ

Gene Symbol	DGKQ
Entrez Gene	1609
Alt Symbol	DAGK, DAGK4, DAGK7
Species	Human
Gene Type	protein-coding
Description	diacylglycerol kinase, theta 110kDa
Other Description	DAG kinase theta|DGK-theta|diacylglycerol kinase theta|diglyceride kinase theta
Swissprots	Q6P3W4 P52824
Accessions	EAW82630 EAW82631 EAW82632 P52824 AB209503 BAD92740 AW139889 BC063801 AAH63801 DN990411 DQ596864 GU727647 ADU87648 L38707 AAA98749 XM_011513411 XP_011511713 XM_011513412 XP_011511714 XM_011513413 XP_011511715 XM_011513414 XP_011511716 XM_011513415 XP_011511717 NM_001347 NP_001338
Function	Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:17664281}.
Subcellular Location	Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. {ECO:0000250}.
Top Pathways	Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

DGKQ Antibody Blocking Peptide - LS-E18643 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DGKQ Antibody Blocking Peptide - LS-E27925 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DGKQ Blocking Peptide - 33R-1847 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DAGK Peptide - AC21-2697-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DGKQ Peptide - 43-064P from ProSci Category Peptide

DGKQ fusion protein - Ag11938 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DGKQ fusion protein - ag11817 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DGKQ, His-tagged - DGKQ-11959H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DGKQ - DGKQ-522H from Creative Biomart Category Protein Source Mammalian Cells Species Human

DGK-θ (S725) Peptide - BS2479P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Diacylglycerol kinase theta(DGKQ) ,partial - CSB-YP006840HU CSB-EP006840HU CSB-BP006840HU CSB-MP006840HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DGKQ, Peptide - MBS427952 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

DGK-theta Recombinant Protein Antigen - NBP1-85317PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DGKQ-Antibody-C-term-Blocking-Peptide - BP8122b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DGKQ-Antibody-N-term-Blocking-Peptide - BP8122a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DGKQ Peptide, Human - M34GP04258H from Creative Peptides Category Peptide Source Synthetic. Species Human

Diacylglycerol kinase theta (DGKQ), partial, Recombinant Protein - MBS964274 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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