DGKQ
| Gene Symbol | DGKQ |
|---|---|
| Entrez Gene | 1609 |
| Alt Symbol | DAGK, DAGK4, DAGK7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | diacylglycerol kinase, theta 110kDa |
| Other Description | DAG kinase theta|DGK-theta|diacylglycerol kinase theta|diglyceride kinase theta |
| Swissprots | Q6P3W4 P52824 |
| Accessions | EAW82630 EAW82631 EAW82632 P52824 AB209503 BAD92740 AW139889 BC063801 AAH63801 DN990411 DQ596864 GU727647 ADU87648 L38707 AAA98749 XM_011513411 XP_011511713 XM_011513412 XP_011511714 XM_011513413 XP_011511715 XM_011513414 XP_011511716 XM_011513415 XP_011511717 NM_001347 NP_001338 |
| Function | Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. {ECO:0000250, ECO:0000269|PubMed:17664281}. |
| Subcellular Location | Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. {ECO:0000250}. |
| Top Pathways | Choline metabolism in cancer, Glycerolipid metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system |
DGK-θ CRISPR/Cas9 KO Plasmid (h) - sc-410754 from Santa Cruz Biotechnology
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DGK-θ HDR Plasmid (h) - sc-410754-HDR from Santa Cruz Biotechnology
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DGK-θ Double Nickase Plasmid (h) - sc-410754-NIC from Santa Cruz Biotechnology
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DGK-θ Double Nickase Plasmid (h2) - sc-410754-NIC-2 from Santa Cruz Biotechnology
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DGK-θ CRISPR Activation Plasmid (h) - sc-410754-ACT from Santa Cruz Biotechnology
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DGK-θ CRISPR Activation Plasmid (h2) - sc-410754-ACT-2 from Santa Cruz Biotechnology
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DGK-θ Lentiviral Activation Particles (h) - sc-410754-LAC from Santa Cruz Biotechnology
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DGK-θ Lentiviral Activation Particles (h2) - sc-410754-LAC-2 from Santa Cruz Biotechnology
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DGK-θ siRNA (h) - sc-45681 from Santa Cruz Biotechnology
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DGK-θ shRNA Plasmid (h) - sc-45681-SH from Santa Cruz Biotechnology
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DGK-θ shRNA (h) Lentiviral Particles - sc-45681-V from Santa Cruz Biotechnology
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DGK-theta RNAi - H00001609-R03 from Novus Biologicals
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MISSION® esiRNA - EHU086951 from Sigma-Aldrich
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MISSION® siRNA - SIHK0592 from Sigma-Aldrich
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MISSION® siRNA - SIHK0593 from Sigma-Aldrich
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MISSION® siRNA - SIHK0594 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7186 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7186 from Sigma-Aldrich
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DGKQ siRNA (Human) - CRH1132 from Cohesion Biosciences
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DGKQ - MBS8234804 from MyBioSource
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shRNA set against Human Dgkq (NM_001347.3) - SHH277533 from Creative biogene
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Human DGKQ siRNA - orb261634 from Biorbyt
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DGKQ shRNA Plasmid (Human) - CHH1132 from Cohesion Biosciences
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DGKQ miRNA 3'UTR clone - MiUTR3H-03947 from Creative biogene
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