| Gene Symbol | EIF3M |
|---|---|
| Entrez Gene | 10480 |
| Alt Symbol | B5, GA17, PCID1, TANGO7, hfl-B5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit M |
| Other Description | B5 receptor|PCI domain containing 1 (herpesvirus entry mediator)|PCI domain-containing protein 1|dendritic cell protein|eukaryotic translation initiation factor 3 subunit M|fetal lung protein B5|transport and golgi organization 7 homolog |
| Swissprots | Q9BXW1 Q53HL6 A8K7X4 Q2F836 B4E2Q4 Q7L2H7 O60735 |
| Accessions | EAW68217 EAW68218 Q7L2H7 AF064603 AAC17108 AF277183 AAK07542 AK001768 AK131064 AK222564 BAD96284 AK292139 BAF84828 AK300002 BAG61821 AK304378 BAG65216 AK307121 AK312512 BAG35413 AV713889 AY769947 AAX12524 BC011937 BC019103 AAH19103 BC020458 BC051292 AAH51292 BE935691 CK002866 CR450300 CAG29296 DB479224 DQ185042 ABD14422 XM_011519840 XP_011518142 XM_011519841 XP_011518143 NM_001307929 NP_001294858 NM_006360 NP_006351 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:15919898, ECO:0000269|PubMed:17403899}. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}. |
| Tissue Specificity | Broadly expressed. {ECO:0000269|PubMed:15919898}. |