| Gene Symbol |
HAS2
|
| Entrez Gene |
3037
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyaluronan synthase 2
|
| Other Description |
HA synthase 2|hyaluronate synthase 2|hyaluronic acid synthase 2
|
| Swissprots |
Q32MM3 Q92819
|
| Accessions |
CAJ87378 CAL40919 CAL44783 CAL47700 EAW92010 Q92819 AJ604570 AK297724 BAG60078 BC069353 AAH69353 BC109071 AAI09072 BC109072 AAI09073 U54804 AAC50692 XM_011517000 XP_011515302 XM_011517001 XP_011515303 XM_011517002 XP_011515304 XM_011517003 XP_011515305 NM_005328 NP_005319
|
| Function |
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in fibroblasts.
|