CAMK2B

Gene Symbol	CAMK2B
Entrez Gene	816
Alt Symbol	CAM2, CAMK2, CAMKB
Species	Human
Gene Type	protein-coding
Description	calcium/calmodulin-dependent protein kinase II beta
Other Description	CaM kinase II beta subunit|CaM-kinase II beta chain|caMK-II subunit beta|calcium/calmodulin-dependent protein kinase type II subunit beta|proline rich calmodulin-dependent protein kinase
Swissprots	Q9UGH8 Q9Y5N4 Q9UGH7 O95437 A4D2K2 A4D2K0 Q9Y6F4 A4D2K4 A4D2K5 Q9UP00 A4D2K6 Q13554 O95438 Q9UNX7 A4D2K1 A4D2K3 Q9UGH9 O95599 Q9UNX0
Accessions	AAS02024 AAS07454 EAL23755 EAL23756 EAL23757 EAL23758 EAL23759 EAL23760 EAL23761 EAL23762 EAW61104 EAW61105 EAW61106 EAW61107 EAW61108 EAW61109 Q13554 AA399393 AB073352 AF078803 AAD42035 AF081572 AAD42036 AF081924 AAD42037 AF083419 AAD42038 AF112471 AAD03743 AF112472 AAD03744 AF131776 AF140350 AAD42070 AI190315 AJ252236 CAB65120 AJ252237 CAB65121 AJ252238 CAB65122 AK091991 AK222703 BAD96423 AK290148 BAF82837 AK294138 BAH11682 AK315663 BAG38029 AM392749 CAL37627 AM392792 CAL37670 AM393562 CAL38439 AM393817 CAL38692 BC019070 AAH19070 BI550751 BQ130578 BX445032 DA069361 DB175099 DB566810 U23460 AAC99802 U50358 AAB16863 XM_005249862 XP_005249919 XM_005249864 XP_005249921 XM_006715781 XP_006715844 XM_006715784 XP_006715847 XM_011515547 XP_011513849 XM_011515548 XP_011513850 XM_011515549 XP_011513851 XM_011515550 XP_011513852 XM_011515551 XP_011513853 XM_011515552 XP_011513854 XM_011515553 XP_011513855 XM_011515554 XP_011513856 XM_011515555 XP_011513857 XM_011515556 XP_011513858 XM_011515557 XP_011513859 XM_011515558 XP_011513860 XM_011515559 XP_011513861 XM_011515560 XP_011513862 NM_001220 NP_001211 NM_001293170 NP_001280099 NM_172078 NP_742075 NM_172079 NP_742076 NM_172080 NP_742077 NM_172081 NP_742078 NM_172082 NP_742079 NM_172083 NP_742080 NM_172084 NP_742081
Function	Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation o
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Note=In slow- twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Tissue Specificity	Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}.
Top Pathways	Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CaMKII beta full length protein - ab132961 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Wheat germ Species Human

Human CaMKII beta full length protein - ab172820 from Abcam Category Protein Prices $210.00 Sizes 10 µg Source E. coli Species Human

Human CaMKII beta protein fragment - ab158020 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Mouse CaMKII beta peptide - ab27843 from Abcam Category Peptide

CAMK2B / CaMKII Beta Antibody Blocking Peptide - LS-E3049 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK2B / CaMKII Beta Antibody Blocking Peptide - LS-E22406 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CAMK2B / CaMKII Beta Antibody Blocking Peptide - LS-E22405 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CaMKII beta Protein - H00000816-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CaMKII beta Protein - H00000816-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CaMKII beta Peptide - P2376 from Novus Biologicals Category Peptide Species Human

CAMK2-beta-Antibody-C-term-Blocking-Peptide - BP7207a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CAMK2B-Antibody-C-term-D406-Blocking-Peptide - BP7417b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CaMK2b peptide - orb72419 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

CAMK2B Blocking Peptide - 33R-10397 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CAMK2B - H00000816-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CAMK2B - H00000816-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CAMK2B - H00000816-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CAMK2B - H00000816-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CAMK2B - P5504 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

CAMK2B, Human, Recombinant - 19-CF55 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

CAMK2B fusion protein - Ag2119 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CAMK2B Enzyme - BP002619-CF55 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CAMK2B, His & GST tagged - CAMK2B-970H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human CAMK2B, GST-tagged - CAMK2B-10682H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CAMK2beta, GST-tagged - CAMK2B-45H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Search more