CAMK2B

Gene Symbol CAMK2B
Entrez Gene 816
Alt Symbol CAM2, CAMK2, CAMKB
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase II beta
Other Description CaM kinase II beta subunit|CaM-kinase II beta chain|caMK-II subunit beta|calcium/calmodulin-dependent protein kinase type II subunit beta|proline rich calmodulin-dependent protein kinase
Swissprots Q9UGH8 Q9Y5N4 Q9UGH7 O95437 A4D2K2 A4D2K0 Q9Y6F4 A4D2K4 A4D2K5 Q9UP00 A4D2K6 Q13554 O95438 Q9UNX7 A4D2K1 A4D2K3 Q9UGH9 O95599 Q9UNX0
Accessions AAS02024 AAS07454 EAL23755 EAL23756 EAL23757 EAL23758 EAL23759 EAL23760 EAL23761 EAL23762 EAW61104 EAW61105 EAW61106 EAW61107 EAW61108 EAW61109 Q13554 AA399393 AB073352 AF078803 AAD42035 AF081572 AAD42036 AF081924 AAD42037 AF083419 AAD42038 AF112471 AAD03743 AF112472 AAD03744 AF131776 AF140350 AAD42070 AI190315 AJ252236 CAB65120 AJ252237 CAB65121 AJ252238 CAB65122 AK091991 AK222703 BAD96423 AK290148 BAF82837 AK294138 BAH11682 AK315663 BAG38029 AM392749 CAL37627 AM392792 CAL37670 AM393562 CAL38439 AM393817 CAL38692 BC019070 AAH19070 BI550751 BQ130578 BX445032 DA069361 DB175099 DB566810 U23460 AAC99802 U50358 AAB16863 XM_005249862 XP_005249919 XM_005249864 XP_005249921 XM_006715781 XP_006715844 XM_006715784 XP_006715847 XM_011515547 XP_011513849 XM_011515548 XP_011513850 XM_011515549 XP_011513851 XM_011515550 XP_011513852 XM_011515551 XP_011513853 XM_011515552 XP_011513854 XM_011515553 XP_011513855 XM_011515554 XP_011513856 XM_011515555 XP_011513857 XM_011515556 XP_011513858 XM_011515557 XP_011513859 XM_011515558 XP_011513860 XM_011515559 XP_011513861 XM_011515560 XP_011513862 NM_001220 NP_001211 NM_001293170 NP_001280099 NM_172078 NP_742075 NM_172079 NP_742076 NM_172080 NP_742077 NM_172081 NP_742078 NM_172082 NP_742079 NM_172083 NP_742080 NM_172084 NP_742081
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation o
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Note=In slow- twitch muscle, evenly distributed between longitudinal SR and junctional SR.
Tissue Specificity Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}.
Top Pathways Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

CaMKIIβ (K-19) - sc-100366 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIIβ (K-19): sc-100366. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human malignant lymphoma, diffuse large B-cell tissue showing membrane and cytoplasmic localization.

Anti-CaMK2 beta gamma delta (phospho T287) antibody - ab182647 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CaMK2 beta gamma delta (phospho T287) antibody (ab182647) at 1/500 dilutionLane 1 : Rat brain lysate.Lane 2 : Rat brain lysate with antigen-specific peptide

Anti-CaMK2 beta gamma delta (phospho T287) antibody - ab192209 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CaMK2 beta gamma delta (phospho T287) antibody (ab192209) at 1/500 dilutionLane 1 : Rat brain tissue lysate with antigen-specific peptideLane 2 : Rat brain tissue lysateLysates/proteins at 12.5 µg per lane.

Anti-CaMK2 beta gamma delta antibody - ab79359 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain tissue using CaMK2-ß/?/d (Ab-287) antibody at 1/50-1/100 dilution.

Anti-CAMK2G + CAMK2B antibody - ab72604 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMK2G + CAMK2B antibody (ab72604) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : COLO205 cell extractLane 3 : COLO205 cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CaMKII beta antibody - ab107163 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CaMKII beta antibody (ab107163) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Brain (Mouse) Tissue LysateLane 3 : Brain (Rat) Tissue LysateLane 4 : Forebrain (Mouse) Tissue Lysate Lane 5 : Rat Cortex Tissue LysateLane 6 : PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell LysateLane 7 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CaMKII beta antibody - ab54926 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
CaMKII beta antibody (ab54926) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human malignant lymphoma, diffuse large B tissue.

Anti-CaMKII beta antibody - ab22131 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining in the rat hippocampal neurons using ab22131 CAMKIIb antibody. This picture was taken using a 40X objective. The staining is observed in the axons and cell bodies of some hippocampal neurons. NB: apart from the hippocampus, most brain areas did not show any staining in this naïve animal. ab22131 was used at 1/100 incubated for 2 days at room temperature. Secondary antibody used was anti-rabbit Alexa Fluor 488 at 1/1000 incubated for 2 hours at room temperature. Rat brain tissue was perfusion fixed with 4% PFA followed by overnight post-fixation in the same fixative, cryoprotected in 20% sucrose and frozen in OCT. 30µm coronal sections were cut on a cyrostat and immunohistochemistry performed by the 'free floating' technique.

Anti-CaMKII beta antibody - C-terminal - ab71709 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CaMKII beta antibody - C-terminal (ab71709) at 1/100 dilutionLane 1 : Jurkat cell lysate Lane 2 : primate lung tissue lysate Lysates/proteins at 12.5 µg per lane.

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 390) - LS-C227304 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 594) - LS-C227310 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 565) - LS-C227309 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 633) - LS-C227311 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody IHC-plus™ - LS-B3743 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CAMK2 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3743 concentration 10 ug/ml.

Anti-CAMK2 / CAMKII Antibody (aa509-558) - LS-C119025 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COLO205/Jurkat cells, using CaMK2 beta/gamma Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 488) - LS-C227312 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody IHC-plus™ - LS-B6850 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Anti-CAMK2 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6850 dilution 1:25.

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 655) - LS-C227313 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286) IHC-plus™ - LS-B2637 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-CAMK2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2637 dilution 1:200.

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Atto 700) - LS-C227314 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, AP) - LS-C227315 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286) - LS-C117312 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human brain, using CaMK2 (Phospho-Thr286) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, APC) - LS-C227317 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (phospho-Thr286/Thr287, clone 22B1, Biotin) - LS-C227318 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1

Anti-CAMK2 / CAMKII Antibody (Met281) - LS-C177502 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of CaMKII/ (M281) pAb in paraffin-embedded human breast carcinoma tissue.
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