CAMK2B
| Gene Symbol | CAMK2B |
|---|---|
| Entrez Gene | 816 |
| Alt Symbol | CAM2, CAMK2, CAMKB |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase II beta |
| Other Description | CaM kinase II beta subunit|CaM-kinase II beta chain|caMK-II subunit beta|calcium/calmodulin-dependent protein kinase type II subunit beta|proline rich calmodulin-dependent protein kinase |
| Swissprots | Q9UGH8 Q9Y5N4 Q9UGH7 O95437 A4D2K2 A4D2K0 Q9Y6F4 A4D2K4 A4D2K5 Q9UP00 A4D2K6 Q13554 O95438 Q9UNX7 A4D2K1 A4D2K3 Q9UGH9 O95599 Q9UNX0 |
| Accessions | AAS02024 AAS07454 EAL23755 EAL23756 EAL23757 EAL23758 EAL23759 EAL23760 EAL23761 EAL23762 EAW61104 EAW61105 EAW61106 EAW61107 EAW61108 EAW61109 Q13554 AA399393 AB073352 AF078803 AAD42035 AF081572 AAD42036 AF081924 AAD42037 AF083419 AAD42038 AF112471 AAD03743 AF112472 AAD03744 AF131776 AF140350 AAD42070 AI190315 AJ252236 CAB65120 AJ252237 CAB65121 AJ252238 CAB65122 AK091991 AK222703 BAD96423 AK290148 BAF82837 AK294138 BAH11682 AK315663 BAG38029 AM392749 CAL37627 AM392792 CAL37670 AM393562 CAL38439 AM393817 CAL38692 BC019070 AAH19070 BI550751 BQ130578 BX445032 DA069361 DB175099 DB566810 U23460 AAC99802 U50358 AAB16863 XM_005249862 XP_005249919 XM_005249864 XP_005249921 XM_006715781 XP_006715844 XM_006715784 XP_006715847 XM_011515547 XP_011513849 XM_011515548 XP_011513850 XM_011515549 XP_011513851 XM_011515550 XP_011513852 XM_011515551 XP_011513853 XM_011515552 XP_011513854 XM_011515553 XP_011513855 XM_011515554 XP_011513856 XM_011515555 XP_011513857 XM_011515556 XP_011513858 XM_011515557 XP_011513859 XM_011515558 XP_011513860 XM_011515559 XP_011513861 XM_011515560 XP_011513862 NM_001220 NP_001211 NM_001293170 NP_001280099 NM_172078 NP_742075 NM_172079 NP_742076 NM_172080 NP_742077 NM_172081 NP_742078 NM_172082 NP_742079 NM_172083 NP_742080 NM_172084 NP_742081 |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation o |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Note=In slow- twitch muscle, evenly distributed between longitudinal SR and junctional SR. |
| Tissue Specificity | Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}. |
| Top Pathways | Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels |
CaMKIIβ siRNA (h) - sc-38951 from Santa Cruz Biotechnology
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CaMKIIβ shRNA Plasmid (h) - sc-38951-SH from Santa Cruz Biotechnology
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CaMKIIβ shRNA (h) Lentiviral Particles - sc-38951-V from Santa Cruz Biotechnology
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CaMKII beta RNAi - H00000816-R13 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R15 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R14 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R09 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R12 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R11 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R10 from Novus Biologicals
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CaMKII beta RNAi - H00000816-R16 from Novus Biologicals
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MISSION® esiRNA - EHU059191 from Sigma-Aldrich
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MISSION® siRNA - SIHK0248 from Sigma-Aldrich
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MISSION® siRNA - SIHK0246 from Sigma-Aldrich
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MISSION® siRNA - SIHK0250 from Sigma-Aldrich
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MISSION® siRNA - SIHK0251 from Sigma-Aldrich
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MISSION® siRNA - SIHK0253 from Sigma-Aldrich
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MISSION® siRNA - SIHK0249 from Sigma-Aldrich
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MISSION® siRNA - SIHK0252 from Sigma-Aldrich
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MISSION® siRNA - SIHK0247 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5316 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5316 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01376 from Sigma-Aldrich
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CAMK2B siRNA (Human) - CRH0570 from Cohesion Biosciences
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CAMK2B - MBS8218124 from MyBioSource
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