| Gene Symbol | S100A8 |
|---|---|
| Entrez Gene | 6279 |
| Alt Symbol | 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | S100 calcium binding protein A8 |
| Other Description | MRP-8|S100 calcium-binding protein A8 (calgranulin A)|calgranulin A|calgranulin-A|calprotectin L1L subunit|cystic fibrosis antigen|leukocyte L1 complex light chain|migration inhibitory factor-related protein 8|protein S100-A8|urinary stone protein band A |
| Swissprots | Q9UC92 D3DV37 P05109 Q9UCJ0 Q9UCM6 A8K5L3 Q5SY70 Q9UC84 |
| Accessions | AAA36327 CAA01001 EAW53330 EAW53331 P05109 AK291328 BAF84017 BC005928 AAH05928 BT007378 AAP36042 BU935536 CR407674 CAG28602 DQ893495 ABM84421 DQ896367 ABM87366 X06234 CAA29580 Y00278 CAA68390 XM_011509861 XP_011508163 NM_002964 NP_002955 |
| Function | S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and |
| Subcellular Location | Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway. |
| Tissue Specificity | Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin ca |
Mouse S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F6832 from LifeSpan Bioscience
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Human S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F4982 from LifeSpan Bioscience
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Rat S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F8024 from LifeSpan Bioscience
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Bovine S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F7917 from LifeSpan Bioscience
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Mouse S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F12538 from LifeSpan Bioscience
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Human S100A8 / MRP8 ELISA Kit (Sandwich ELISA) - LS-F12537 from LifeSpan Bioscience
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Human S100A8 / Protein S100-A8 ELISA Kit - RAB0730 from Sigma-Aldrich
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Human S100A8 DuoSet ELISA - DY4570-05 from R&D Systems
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Mouse S100A8 DuoSet ELISA - DY3059 from R&D Systems
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Human MIF ELISA Kit - 55R-1760 from Fitzgerald
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Human Mullerian hormone ELISA kit - 55R-2108 from Fitzgerald
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Human MIF ELISA Kit - orb219485 from Biorbyt
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Human Calgranulin A ELISA Kit - abx052135 from Abbexa
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Human MIF ELISA Kit - abx056271 from Abbexa
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Human MIF ELISA Kit - abx056272 from Abbexa
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Human MIF ELISA kit - abx050153 from Abbexa
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Human MIF ELISA Kit - abx054576 from Abbexa
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Human MIF ELISA Kit - abx152334 from Abbexa
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Anti-Mullerian hormone (AMH), Human, ELISA Kit - CSB-E12756h from ARP American Research Products
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Anti-Mullerian Hormone (AMH), Human, ELISA Kit - CEA228Hu from ARP American Research Products
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ATP Binding Cassette Transporter C11 (ABCC11), Human, ELISA Kit - SED631Hu from ARP American Research Products
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Cytotoxin-associated protein (CagA) antibody (IgG), Human, ELISA Kit - E01C1310 from ARP American Research Products
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Cytotoxin-associated protein (CagA) antibody (IgG), Human, ELISA kit - CSB-EQ027541HU from ARP American Research Products
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Cytotoxin-associated protein (CagA), Human, ELISA Kit - CSB-E09170h from ARP American Research Products
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Cytotoxin-associated protein (CagA), Human, ELISA Kit - E01C1309 from ARP American Research Products
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