S100A8

Gene Symbol	S100A8
Entrez Gene	6279
Alt Symbol	60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8
Species	Human
Gene Type	protein-coding
Description	S100 calcium binding protein A8
Other Description	MRP-8|S100 calcium-binding protein A8 (calgranulin A)|calgranulin A|calgranulin-A|calprotectin L1L subunit|cystic fibrosis antigen|leukocyte L1 complex light chain|migration inhibitory factor-related protein 8|protein S100-A8|urinary stone protein band A
Swissprots	Q9UC92 D3DV37 P05109 Q9UCJ0 Q9UCM6 A8K5L3 Q5SY70 Q9UC84
Accessions	AAA36327 CAA01001 EAW53330 EAW53331 P05109 AK291328 BAF84017 BC005928 AAH05928 BT007378 AAP36042 BU935536 CR407674 CAG28602 DQ893495 ABM84421 DQ896367 ABM87366 X06234 CAA29580 Y00278 CAA68390 XM_011509861 XP_011508163 NM_002964 NP_002955
Function	S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and
Subcellular Location	Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.
Tissue Specificity	Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin ca

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MRP8 full length protein - ab167749 from Abcam Category Protein Prices $302.00 Sizes 100 µg Source E. coli Species Human

Human MRP8 + MRP14 full length protein - ab130945 from Abcam Category Protein Source E. coli Species Human

Human MRP8 + MRP14 full length protein - ab151203 from Abcam Category Protein Species Human

Human MRP8 full length protein - ab95343 from Abcam Category Protein Source E. coli Species Human

Human MRP8 full length protein - ab194153 from Abcam Category Protein Source Mammalian Species Human

Human MRP8 full length protein - ab194171 from Abcam Category Protein Source Mammalian Species Human

Human MRP8 peptide - ab100827 from Abcam Category Peptide

Mouse MRP8 full length protein - ab108120 from Abcam Category Protein Source E. coli Species Mouse

MIF Antibody Blocking Peptide - LS-E20441 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MIF Antibody Blocking Peptide - LS-E25882 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S100A8 / MRP8 Antibody Blocking Peptide - LS-E25167 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S100A8 / MRP8 Antibody Blocking Peptide - LS-E27888 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MIF Protein - NBP2-34998 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

Recombinant Human S100A8 Protein - NBP1-44482 from Novus Biologicals Category Protein Prices $379.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human MIF His (C-Term) Protein - NBP2-35005 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

Recombinant Human S100A8 Protein - H00006279-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

MIF Recombinant Protein - H00004282-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

S100A8 Partial Recombinant Protein - H00006279-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human MIF Protein - NBC1-18487 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human MIF Protein - P4426 from Novus Biologicals Category Protein Prices $449.00 Sizes 25 µg Source E. coli Species Human

MIF Protein - NBP1-99545 from Novus Biologicals Category Protein Prices $349.00 Sizes 10 µg Species Human

MIF Protein - NBP1-99769 from Novus Biologicals Category Protein Species Human

MIF Protein - NBP1-43181 from Novus Biologicals Category Protein Prices $289.00 Sizes 5 µg

ABCC11 blocking peptide - GTX88673-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

S100A9 blocking peptide - GTX88481-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

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