POLR2D

Gene Symbol	POLR2D
Entrez Gene	5433
Alt Symbol	HSRBP4, HSRPB4, RBP4, RPB16
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) II (DNA directed) polypeptide D
Other Description	DNA-directed RNA polymerase II 16 kDa polypeptide|DNA-directed RNA polymerase II subunit D|DNA-directed RNA polymerase II subunit RPB4|RNA polymerase II 16 kDa subunit|RNA polymerase II subunit B4|RNA polymerase II subunit hsRBP4
Swissprots	O15514 Q52LT4
Accessions	AAC52056 AAX82034 AAY14877 EAW95344 EAW95345 O15514 AA775787 BC002958 BC010427 AAH10427 BC017205 AAH17205 BC093795 AAH93795 BC093797 AAH93797 U85510 AAC80226 NM_004805 NP_004796
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways	Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Anti-RNA polymerase II RPB4 antibody - ab186868 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-RNA polymerase II RPB4 antibody - ab57301 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, AP) - LS-C223696 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, APC) - LS-C223697 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, Biotin) - LS-C223698 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, FITC) - LS-C223699 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, Azide-free, HRP) - LS-C223700 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79, PE) - LS-C223701 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa48-79) - LS-C324167 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody - LS-C341360 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (clone 1E4-A5) - LS-C197944 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E4-A5

Anti-RPB16 / POLR2D Antibody - LS-C331733 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RPB16 / POLR2D Antibody (aa51-79) - LS-C158697 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

POLR2D Antibody - NBP1-92280 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

POLR2D Antibody (1E4-A5) - H00005433-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E4-A5

POLR2D Antibody - H00005433-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Monoclonal Anti-POLR2D antibody produced in mouse - WH0005433M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E4-A5

Anti-POLR2D antibody produced in rabbit - HPA046092 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RBP4 Antibody (OAPA00308) - OAPA00308 from Aviva Systems Biology Prices $100.00 Sizes 5 µg Host Mouse Clonality Monoclonal Clone PAT2B4AT.

POLR2D-Antibody-Center - AP17215c from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

POLR2D-Antibody-monoclonal-M01 - AT3375a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E4-A5

POLR2D Antibody - middle region (OAAB12642) - OAAB12642 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

POLR2D Polyclonal Antibody - A1859 from ABclonal Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

POLR2D antibody - orb192388 from Biorbyt Prices $536.00 Sizes 100 μl Host Rabbit Clonality Polyclonal

POLR2D antibody - 70R-19406 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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