| Gene Symbol |
POLR2D
|
| Entrez Gene |
5433
|
| Alt Symbol |
HSRBP4, HSRPB4, RBP4, RPB16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide D
|
| Other Description |
DNA-directed RNA polymerase II 16 kDa polypeptide|DNA-directed RNA polymerase II subunit D|DNA-directed RNA polymerase II subunit RPB4|RNA polymerase II 16 kDa subunit|RNA polymerase II subunit B4|RNA polymerase II subunit hsRBP4
|
| Swissprots |
O15514 Q52LT4
|
| Accessions |
AAC52056 AAX82034 AAY14877 EAW95344 EAW95345 O15514 AA775787 BC002958 BC010427 AAH10427 BC017205 AAH17205 BC093795 AAH93795 BC093797 AAH93797 U85510 AAC80226 NM_004805 NP_004796
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9852112}.
|
| Top Pathways |
Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|