POLR2D

Gene Symbol	POLR2D
Entrez Gene	5433
Alt Symbol	HSRBP4, HSRPB4, RBP4, RPB16
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) II (DNA directed) polypeptide D
Other Description	DNA-directed RNA polymerase II 16 kDa polypeptide|DNA-directed RNA polymerase II subunit D|DNA-directed RNA polymerase II subunit RPB4|RNA polymerase II 16 kDa subunit|RNA polymerase II subunit B4|RNA polymerase II subunit hsRBP4
Swissprots	O15514 Q52LT4
Accessions	AAC52056 AAX82034 AAY14877 EAW95344 EAW95345 O15514 AA775787 BC002958 BC010427 AAH10427 BC017205 AAH17205 BC093795 AAH93795 BC093797 AAH93797 U85510 AAC80226 NM_004805 NP_004796
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9852112}.
Top Pathways	Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNA polymerase II RPB4 full length protein - ab159154 from Abcam Category Protein Source Wheat germ Species Human

Human RNA polymerase II RPB4 full length protein - ab168087 from Abcam Category Protein Source E. coli Species Human

RPB16 / POLR2D Antibody Blocking Peptide - LS-E4834 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLR2D Recombinant Protein - H00005433-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

POLR2D Protein - NBP2-23343 from Novus Biologicals Category Protein Prices $309.00 Sizes 100 µg Species Human

POLR2D-Antibody-Center-Blocking-Peptide - BP17215c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human POLR2D protein - orb191433 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli. Species Human

POLR2D protein (His tag) - 80R-2971 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

POLR2D (1-142, His-tag) - AR51089PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

POLR2D (1-142, His-tag) - AR51089PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

POLR2D - H00005433-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POLR2D - H00005433-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLR2D, 1-142aa, Human, His tag, E.coli - 01-P2265 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

POLR2D fusion protein - Ag8918 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

POLR2D fusion protein - Ag8701 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human POLR2D, His-tagged - POLR2D-15909H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human POLR2D, His-tagged - POLR2D-1842H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DNA-directed RNA polymerase II subunit RPB4(POLR2D) - CSB-YP018331HU CSB-EP018331HU CSB-BP018331HU CSB-MP018331HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

POLR2D, 1-142aa, Human, His tag, E.coli (Denatured) - ATGP2265 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

POLR2D - TP301116 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLR2D, Recombinant Protein - MBS204821 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

Polymerase II Polypeptide D, Recombinant Protein - MBS145700 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg Source E Coli

POLR2D Recombinant Protein Antigen - NBP1-92280PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR2D Peptide, Human - M34GP12092H from Creative Peptides Category Peptide Source Synthetic. Species Human

Polymerase II Polypeptide D, Human Recombinant - 228-20686-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

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