| Gene Symbol |
TET3
|
| Entrez Gene |
200424
|
| Alt Symbol |
hCG_40738
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tet methylcytosine dioxygenase 3
|
| Other Description |
methylcytosine dioxygenase TET3|probable methylcytosine dioxygenase TET3|putative methylcytosine dioxygenase|tet oncogene family member 3
|
| Swissprots |
Q86Z24 O43151 A6NEI3 Q8TBM9
|
| Accessions |
AAX93057 EAW99702 O43151 AB007861 BAA23697 AF466365 AAO33386 AI348471 BC022243 AAH22243 HG494202 HQ220209 ADU77107 XM_005264187 XP_005264244 XM_011532682 XP_011530984 XM_011532683 XP_011530985 XM_011532684 XP_011530986 XM_011532685 XP_011530987 XM_011532686 XP_011530988 XM_011532687 XP_011530989 XM_011532688 XP_011530990 XM_011532689 XP_011530991 XM_011532690 XP_011530992 NM_144993 NM_001287491 NP_001274420
|
| Function |
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. {ECO:0000269|PubMed:12646957}.
|