TET3

Gene Symbol	TET3
Entrez Gene	200424
Alt Symbol	hCG_40738
Species	Human
Gene Type	protein-coding
Description	tet methylcytosine dioxygenase 3
Other Description	methylcytosine dioxygenase TET3|probable methylcytosine dioxygenase TET3|putative methylcytosine dioxygenase|tet oncogene family member 3
Swissprots	Q86Z24 O43151 A6NEI3 Q8TBM9
Accessions	AAX93057 EAW99702 O43151 AB007861 BAA23697 AF466365 AAO33386 AI348471 BC022243 AAH22243 HG494202 HQ220209 ADU77107 XM_005264187 XP_005264244 XM_011532682 XP_011530984 XM_011532683 XP_011530985 XM_011532684 XP_011530986 XM_011532685 XP_011530987 XM_011532686 XP_011530988 XM_011532687 XP_011530989 XM_011532688 XP_011530990 XM_011532689 XP_011530991 XM_011532690 XP_011530992 NM_144993 NM_001287491 NP_001274420
Function	Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. {ECO:0000250}.
Tissue Specificity	Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. {ECO:0000269|PubMed:12646957}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TET3 full length protein - ab153625 from Abcam Category Protein Source Wheat germ Species Human

Human TET3 protein fragment - ab172188 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

TET3 Antibody Blocking Peptide - LS-E31324 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human TET3 Protein - H00200424-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MGC22014 - H00200424-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MGC22014 (C-term) Control Peptide - AP55486CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TET3 Peptide - 7013P from ProSci Category Peptide Species Human

TET3 fusion protein - ag18335 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human TET3, GST-tagged - TET3-161H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

TET3 protein-GST fusion - 009-001-U15 from Rockland Immunochemicals Inc Category Protein Prices $599.00 Sizes 50 µg Species Human

TET3 protein-GST fusion - 009-001-U15S from Rockland Immunochemicals Inc Category Protein Prices $315.00 Sizes 20 µg Species Human

Recombinant Human Methylcytosine dioxygenase TET3(TET3) ,partial - CSB-YP023398HU CSB-EP023398HU CSB-BP023398HU CSB-MP023398HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Tet3 (824-1795) protein - 31421 from ActiveMotif Category Protein Prices $395.00 Sizes 10 µg Source Baculovirus Species Human

TET3 fusion protein - ag18379 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

TET3 Protein - abx163654 from Abbexa Category Protein Species Human, Mouse

TET3, Recombinant Protein - MBS515283 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

TET3 Recombinant Protein Antigen - NBP2-13427PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TET3 Peptide, Human - M34GP15806H from Creative Peptides Category Peptide Source Synthetic. Species Human

TET3 fusion protein - Ag25891 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

TET3 fusion protein - Ag25877 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Methylcytosine dioxygenase TET3 (TET3), partial, Recombinant Protein - MBS1206841 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more