TET3

Gene Symbol TET3
Entrez Gene 200424
Alt Symbol hCG_40738
Species Human
Gene Type protein-coding
Description tet methylcytosine dioxygenase 3
Other Description methylcytosine dioxygenase TET3|probable methylcytosine dioxygenase TET3|putative methylcytosine dioxygenase|tet oncogene family member 3
Swissprots Q86Z24 O43151 A6NEI3 Q8TBM9
Accessions AAX93057 EAW99702 O43151 AB007861 BAA23697 AF466365 AAO33386 AI348471 BC022243 AAH22243 HG494202 HQ220209 ADU77107 XM_005264187 XP_005264244 XM_011532682 XP_011530984 XM_011532683 XP_011530985 XM_011532684 XP_011530986 XM_011532685 XP_011530987 XM_011532686 XP_011530988 XM_011532687 XP_011530989 XM_011532688 XP_011530990 XM_011532689 XP_011530991 XM_011532690 XP_011530992 NM_144993 NM_001287491 NP_001274420
Function Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. {ECO:0000250}.
Tissue Specificity Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. {ECO:0000269|PubMed:12646957}.

TET3 (T-13) - sc-139186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TET3 (T-13): sc-139186. Western blot analysis of TET3 expression in non-transfected: sc-117752 (A) and truncated human TET3 transfected: sc-373361 (B) 293T whole cell lysates.

Anti-TET3 antibody - ab139805 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of TET3 in Human brain tissue with ab139805 at 20 ug/mL.

Anti-TET3 antibody - ab139311 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TET3 antibody (ab139311) at 1/500 dilutionLane 1 : Human Jurkat cell extractLane 2 : Mouse thymus cell extract

Anti-TET3 antibody - ab135033 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TET3 antibody (ab135033) at 1/500 dilution + Mouse thymus cell extract

Anti-TET3 antibody - ab128216 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TET3 antibody (ab128216) at 1 µg/mlLane 1 : 293T cell line transfected with TET3Lane 2 : non-transfected 293T cell line lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG at 2500

Anti-TET3 antibody - ab135036 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-TET3 antibody (ab135036) at 1/500 dilution + Jurkat total cell extract

Anti-TET3 antibody [2B7] - N-terminal - ab174862 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B7
All lanes : Anti-TET3 antibody [2B7] - N-terminal (ab174862) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : Jurkat total cell extract

Anti-TET3 antibody [4D5] - ab139321 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 4D5
Overlay histogram showing HeLa cells stained with ab139321 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab139321, 1/50 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgM (mu chain) (ab97007) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgM [ICIGM] (ab91545, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-TET3 antibody - C-terminal - ab153724 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of TET3 in Immunoprecipitate of TET3-transfected 293T cells. Lane 1: Transfected 293T cell lysate. Lane 2: Control with 2 µg of preimmune rabbit IgG Lane 3: Immunoprecipitate of TET3-transfected 293T cells using ab153724 at 2 µg. Detection using ab153724 at 1/1000 dilution.

Anti-TET3 Antibody (aa241-568, clone 5A4) - LS-C338917 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A4
Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.

Anti-TET3 Antibody (aa241-568, clone 11H8) - LS-C338936 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11H8
Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.

Anti-TET3 Antibody (aa241-568, clone 3B3) - LS-C338935 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B3
Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.

Anti-TET3 Antibody (aa241-568, clone 3G10) - LS-C338921 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G10
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-TET3 Antibody - LS-C335296 from LifeSpan Bioscience

Prices $315.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of 293T cell lines, using TET3 antibody.

Anti-TET3 Antibody (aa241-568, clone 10G4) - LS-C338950 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10G4
Human recombinant protein fragment corresponding to amino acids 241-568 of human TET3 (NP_659430) produced in E.coli.

Anti-TET3 Antibody (aa241-568, clone 15H3) - LS-C338951 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 15H3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TET3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TET3.

Anti-TET3 Antibody (aa241-568, clone 2F10) - LS-C338948 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2F10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TET3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TET3.

Anti-TET3 Antibody (aa241-568, clone 4B7) - LS-C338952 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B7
IHC of paraffin-embedded Human tonsil using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-TET3 Antibody (aa241-568, clone 11E11) - LS-C338949 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11E11
IHC of paraffin-embedded Human tonsil using anti-TET3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-TET3 Antibody (C-Terminus) IHC-plus™ - LS-B8858 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TET3 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TET3 Antibody - NBP2-20602 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TET3 Antibody [NBP2-20602] - A. 30 ug 293T whole cell lysate/extract B. 30 ug whole cell lysate/extract of Flag-human TET3-transfected 293T cells 5% SDS-PAGE TET3 antibody [C3], C-term dilution: 1:5000.

TET3 Antibody - NBP2-13427 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: TET3 Antibody [NBP2-13427] - Staining of human cell line MCF7 shows localization to nucleoplasm, cytosol & vesicles. Antibody staining is shown in green.

TET3 Antibody - NBP2-20603 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TET3 Antibody [NBP2-20603] - A. 30 ug 293T whole cell lysate/extractB. 30 ug whole cell lysate/extract of Flag-human TET3-transfected 293T cells5 % SDS-PAGE TET3 antibody [N3C1], Internal dilution: 1:5000.

TET3 Antibody - NBP2-20601 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

TET3 Antibody - H00200424-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
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