| Gene Symbol |
COPB2
|
| Entrez Gene |
9276
|
| Alt Symbol |
beta'-COP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
coatomer protein complex, subunit beta 2 (beta prime)
|
| Other Description |
beta'-coat protein|betaprime-COP|coatomer binding complex, beta prime subunit|coatomer subunit beta'|p102
|
| Swissprots |
B4DZI8 P35606
|
| Accessions |
CAJ42726 EAW79039 EAW79040 P35606 AK128561 AK302943 BAG64100 AK304219 BAG65091 BC000326 AAH00326 DC347783 DC385126 JF432305 ADZ15522 X70476 CAA49900 XM_011513317 XP_011511619 NM_004766 NP_004757 NR_023350
|
| Function |
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. {ECO:0000250}.
|