KCNH2
| Gene Symbol | KCNH2 |
|---|---|
| Entrez Gene | 3757 |
| Alt Symbol | ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated eag related subfamily H, member 2 |
| Other Description | eag homolog|eag-related protein 1|ether-a-go-go-related gene potassium channel 1|ether-a-go-go-related potassium channel protein|ether-a-go-go-related protein 1|potassium voltage-gated channel subfamily H member 2|potassium voltage-gated channel, subfamily H (eag-related), member 2|voltage-gated potassium channel subunit Kv11.1 |
| Swissprots | O75418 O75680 Q9BUT7 D3DX04 C4PFH9 Q9BT72 Q9H3P0 A5H1P7 Q12809 Q708S9 |
| Accessions | AAQ91589 AAQ91590 AAQ91591 AAQ91592 AAQ91593 AAQ91594 AAQ91595 AAQ91596 AAQ91597 AAQ91598 AAQ91599 AAQ91600 AAQ91601 AAS07566 AAS07567 ABQ01243 ABW98495 ACN88550 ACT31321 AEL63844 AFR51950 BAA37096 CAA09232 CAJ13411 CAJ13412 CAJ18800 CAJ18801 EAL24491 EAL24492 EAL24493 EAW54071 EAW54072 EAW54073 EAW54074 EAW54075 Q12809 AB044806 BAB19682 AF052728 AAC69709 AF363636 AAL37559 AJ512214 CAD54447 AJ609614 CAE82156 AY927502 BC001914 AAH01914 BC004311 AAH04311 BC127672 BC127673 AAI27674 BC167862 AAI67862 BG683210 BM674996 BQ478289 BQ890248 BT007336 AAP36000 DQ120124 AAZ40507 DQ120125 AAZ40508 DQ525913 ABF71886 FJ938021 ACR24650 U04270 AAA62473 XM_011516185 XP_011514487 XM_011516186 XP_011514488 NM_000238 NP_000229 NM_001204798 NP_001191727 NM_172056 NP_742053 NM_172057 NP_742054 |
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. {ECO:0000269|PubMed:18559421}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:19412172}; Multi-pass membrane protein {ECO:0000269|PubMed:18559421, ECO:0000269|PubMed:19412172}. |
| Tissue Specificity | Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells. {ECO:0000269|PubMed:18559421}. |
Ergtoxin full length protein - ab57374 from Abcam
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Human KCNH2 protein fragment - ab152488 from Abcam
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ERG-1 / CUZD1 Antibody Blocking Peptide - LS-E786 from LifeSpan Bioscience
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ERG1 / SQLE Antibody Blocking Peptide - LS-E1815 from LifeSpan Bioscience
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KCNH2 / HERG Blocking Peptide - LS-E12604 from LifeSpan Bioscience
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KCNH2 / HERG Antibody Blocking Peptide - LS-E12442 from LifeSpan Bioscience
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KCNH2 / HERG Antibody Blocking Peptide - LS-E9793 from LifeSpan Bioscience
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KCNH2 / HERG Antibody Blocking Peptide - LS-E29685 from LifeSpan Bioscience
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KCNH2 / HERG Antibody Blocking Peptide - LS-E29686 from LifeSpan Bioscience
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Recombinant Human Kv11.1 Protein - H00003757-Q01 from Novus Biologicals
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Recombinant Human Kv11.1 Protein - H00003757-G01-10ug from Novus Biologicals
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KCNH2-Antibody-Center-Blocking-Peptide - BP8811c from Abgent, a WuXi AppTec company
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KCNH2 Blocking Peptide - 33R-8732 from Fitzgerald
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KCNH2 - H00003757-Q01-10 from Acris Antibodies
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KCNH2 - H00003757-Q01-25 from Acris Antibodies
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KCNH2 fusion protein - ag13875 from Proteintech Group
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KCNH2 fusion protein - ag14836 from Proteintech Group
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PrecisION™ hERG ion channel membrane preparation - CYL4039 from EMD Millipore
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Recombinant CUB And Zona Pellucida Like Domains Protein 1 (CUZD1) - RPQ635Hu01 from Cloud-clone
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Kv11.1 Protein - NBP2-38472PEP from Novus Biologicals
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Kv11.1 Protein - NBP2-38797PEP from Novus Biologicals
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KCNH2 Peptide, Human - M34GP07949H from Creative Peptides
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