| Gene Symbol |
MIIP
|
| Entrez Gene |
60672
|
| Alt Symbol |
IIP45
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
migration and invasion inhibitory protein
|
| Other Description |
IGFBP2-binding protein|invasion-inhibitory protein 45|migration and invasion-inhibitory protein
|
| Swissprots |
Q96HU6 C0KL22 Q5JXC2 Q9H839 Q9HA00
|
| Accessions |
EAW71729 Q5JXC2 AK022500 BAB14062 AK024020 BAB14781 AK095928 AW196459 BC008068 AAH08068 BG536799 BI828925 FJ618905 ACM90320 HQ447804 ADQ32288 XM_005263487 XP_005263544 XM_011541895 XP_011540197 XM_011541896 XP_011540198 NM_021933 NP_068752 NM_001025374
|
| Function |
Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}.
|
| Tissue Specificity |
Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. {ECO:0000269|PubMed:14617774}.
|