Gene Symbol | MIIP |
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Entrez Gene | 60672 |
Alt Symbol | IIP45 |
Species | Human |
Gene Type | protein-coding |
Description | migration and invasion inhibitory protein |
Other Description | IGFBP2-binding protein|invasion-inhibitory protein 45|migration and invasion-inhibitory protein |
Swissprots | Q96HU6 C0KL22 Q5JXC2 Q9H839 Q9HA00 |
Accessions | EAW71729 Q5JXC2 AK022500 BAB14062 AK024020 BAB14781 AK095928 AW196459 BC008068 AAH08068 BG536799 BI828925 FJ618905 ACM90320 HQ447804 ADQ32288 XM_005263487 XP_005263544 XM_011541895 XP_011540197 XM_011541896 XP_011540198 NM_021933 NP_068752 NM_001025374 |
Function | Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. {ECO:0000269|PubMed:14617774}. |
Tissue Specificity | Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. {ECO:0000269|PubMed:14617774}. |
IIp45 CRISPR/Cas9 KO Plasmid (h) - sc-412947 from Santa Cruz Biotechnology
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IIp45 HDR Plasmid (h) - sc-412947-HDR from Santa Cruz Biotechnology
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IIp45 Double Nickase Plasmid (h) - sc-412947-NIC from Santa Cruz Biotechnology
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IIp45 Double Nickase Plasmid (h2) - sc-412947-NIC-2 from Santa Cruz Biotechnology
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IIp45 CRISPR Activation Plasmid (h) - sc-412947-ACT from Santa Cruz Biotechnology
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IIp45 CRISPR Activation Plasmid (h2) - sc-412947-ACT-2 from Santa Cruz Biotechnology
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IIp45 Lentiviral Activation Particles (h) - sc-412947-LAC from Santa Cruz Biotechnology
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IIp45 Lentiviral Activation Particles (h2) - sc-412947-LAC-2 from Santa Cruz Biotechnology
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IIp45 siRNA (h) - sc-88569 from Santa Cruz Biotechnology
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IIp45 shRNA Plasmid (h) - sc-88569-SH from Santa Cruz Biotechnology
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IIp45 shRNA (h) Lentiviral Particles - sc-88569-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU156391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13330 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13330 from Sigma-Aldrich
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MIIP siRNA (Human) - CRJ1823 from Cohesion Biosciences
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shRNA set against Human MIIP (NM_021933.3) - SHH342003 from Creative biogene
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Human MIIP siRNA - orb272324 from Biorbyt
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MIIP shRNA Plasmid (Human) - CHJ1823 from Cohesion Biosciences
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MIIP miRNA 3'UTR clone - MiUTR3H-10218 from Creative biogene
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