| Gene Symbol |
NRGN
|
| Entrez Gene |
4900
|
| Alt Symbol |
RC3, hng
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neurogranin (protein kinase C substrate, RC3)
|
| Other Description |
calmodulin-binding protein|neurogranin|ng|protein kinase C substrate
|
| Swissprots |
Q92686
|
| Accessions |
CAA67532 CAA67533 CAA75343 CAC37631 EAW67593 EAW67594 Q92686 BC002835 AAH02835 BM923818 BT007325 AAP35989 DB474181 U89165 AAB49458 Y09689 CAA70867 NM_001126181 NP_001119653 NM_006176 NP_006167
|
| Function |
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. {ECO:0000269|PubMed:9329454}.
|