Gene Symbol | NRGN |
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Entrez Gene | 4900 |
Alt Symbol | RC3, hng |
Species | Human |
Gene Type | protein-coding |
Description | neurogranin (protein kinase C substrate, RC3) |
Other Description | calmodulin-binding protein|neurogranin|ng|protein kinase C substrate |
Swissprots | Q92686 |
Accessions | CAA67532 CAA67533 CAA75343 CAC37631 EAW67593 EAW67594 Q92686 BC002835 AAH02835 BM923818 BT007325 AAP35989 DB474181 U89165 AAB49458 Y09689 CAA70867 NM_001126181 NP_001119653 NM_006176 NP_006167 |
Function | Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}. |
Tissue Specificity | In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. {ECO:0000269|PubMed:9329454}. |
Neurogranin CRISPR/Cas9 KO Plasmid (h) - sc-404119 from Santa Cruz Biotechnology
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Neurogranin HDR Plasmid (h) - sc-404119-HDR from Santa Cruz Biotechnology
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Neurogranin Double Nickase Plasmid (h) - sc-404119-NIC from Santa Cruz Biotechnology
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Neurogranin Double Nickase Plasmid (h2) - sc-404119-NIC-2 from Santa Cruz Biotechnology
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Neurogranin CRISPR Activation Plasmid (h) - sc-404119-ACT from Santa Cruz Biotechnology
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Neurogranin CRISPR Activation Plasmid (h2) - sc-404119-ACT-2 from Santa Cruz Biotechnology
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Neurogranin Lentiviral Activation Particles (h) - sc-404119-LAC from Santa Cruz Biotechnology
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Neurogranin Lentiviral Activation Particles (h2) - sc-404119-LAC-2 from Santa Cruz Biotechnology
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Neurogranin siRNA (h) - sc-42074 from Santa Cruz Biotechnology
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Neurogranin shRNA Plasmid (h) - sc-42074-SH from Santa Cruz Biotechnology
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Neurogranin shRNA (h) Lentiviral Particles - sc-42074-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15512 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15512 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06486 from Sigma-Aldrich
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NRGN siRNA (Human) - CRH3256 from Cohesion Biosciences
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shRNA set against Human NRGN (NM_006176.2) - SHH355080 from Creative biogene
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Human NRGN siRNA - orb263758 from Biorbyt
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NRGN shRNA Plasmid (Human) - CHH3256 from Cohesion Biosciences
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NRGN miRNA 3'UTR clone - MiUTR3H-04900 from Creative biogene
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NRGN miRNA 3'UTR clone - MiUTR3H-04901 from Creative biogene
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