RNF19B

Gene Symbol	RNF19B
Entrez Gene	127544
Alt Symbol	IBRDC3, NKLAM
Species	Human
Gene Type	protein-coding
Description	ring finger protein 19B
Other Description	E3 ubiquitin-protein ligase RNF19B\|IBR domain-containing protein 3\|natural killer lytic-associated molecule
Swissprots	Q6P6A4 Q0VG77 B7ZLB2 Q8WUF3 E9PAW6 Q5TH45 Q8N2S8 G3XA82 Q6ZMZ0 Q5TH44
Accessions	CAF85699 EAX07489 EAX07490 EAX07491 Q6ZMZ0 AA194237 AK074486 BAC11017 AK131439 BAD18585 BC020595 AAH20595 BC062374 AAH62374 BC113560 AAI13561 BC143687 AAI43688 DA630289 XM_006710356 XP_006710419 XM_006710357 XP_006710420 XM_006710358 XP_006710421 NM_001127361 NP_001120833 NM_001300826 NP_001287755 NM_153341 NP_699172
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. {ECO:0000269\|PubMed:10438909, ECO:0000269\|PubMed:16709802}.
Subcellular Location	Cytoplasmic granule membrane {ECO:0000269\|PubMed:10438909}; Multi-pass membrane protein {ECO:0000269\|PubMed:10438909}.
Tissue Specificity	Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level). {ECO:0000269\|PubMed:10438909, ECO:0000269\|PubMed:10912506}.

NKLAM (E-15) - sc-165113 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

NKLAM (K-12) - sc-165115 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-RNF19B antibody - ab108045 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B antibody (ab108045) at 1/100 dilution + MCF-7 cell lysate at 35 µg

Anti-RNF19B antibody - ab186483 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B antibody (ab186483) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-RNF19B antibody - C-terminal - ab180015 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B antibody - C-terminal (ab180015) at 1 µg/ml + 721_B whole cell lysate at 10 µg

Anti-RNF19B Antibody (aa369-398, APC) - LS-C268395 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa369-398, AP) - LS-C268396 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa369-398, Biotin) - LS-C268397 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa369-398, FITC) - LS-C268398 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa369-398, Azide-free, HRP) - LS-C268399 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa376-405) - LS-C324735 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa369-398, PE) - LS-C268402 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B Antibody (aa613-662) - LS-C201906 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human 721_B. RNF19B antibody dilution 1.0 ug/ml.

Anti-RNF19B Antibody (aa381-430) - LS-C205989 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RNF19B antibody Western Blot of Jurkat. Antibody dilution: 1 ug/ml.

Anti-RNF19B Antibody (aa369-398) - LS-C162654 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The RNF19B antibody detected the RNF19B protein (arrow).

RNF19B Antibody - NBP2-14688 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: RNF19B Antibody [NBP2-14688] - Immunofluorescent staining of human cell line A-431 shows localization to cytosol.

RNF19B Polyclonal Antibody - bs-9246R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RNF19B antibody produced in rabbit - HPA049587 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-RNF19B:<B>Cat. No. HPA049587</B>: Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in germinal center cells and non-germinal center cells.

ANTI-RNF19B (CENTER) antibody produced in rabbit - SAB1301675 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-RNF19B (Center): <B>Cat. No. SAB1301675 </B>: RNF19B Antibody (Center) western blot analysis in MCF-7 cell line lysates (35 μg/lane).

RNF19B Antibody - C-terminal region (ARP71547_P050) - ARP71547_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B Antibody - C-terminal region (ARP71548_P050) - ARP71548_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B-Antibody-Center - AP11179c from Abgent, a WuXi AppTec company

Prices	$99.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B Antibody (Center) (Cat. #AP11179c) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

RNF19B Antibody - middle region (OAAB07423) - OAAB07423 from Aviva Systems Biology

Prices	$289.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B (Center) antibody - AP53688PU-N from Acris Antibodies

Prices	$330.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

RNF19B antibody - H00127544-B01P from Acris Antibodies

Prices	$1,530.00
Sizes	500 µg
Host	Mouse
Clonality	Polyclonal

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