| Gene Symbol |
RNF19B
|
| Entrez Gene |
127544
|
| Alt Symbol |
IBRDC3, NKLAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 19B
|
| Other Description |
E3 ubiquitin-protein ligase RNF19B|IBR domain-containing protein 3|natural killer lytic-associated molecule
|
| Swissprots |
Q6P6A4 Q0VG77 B7ZLB2 Q8WUF3 E9PAW6 Q5TH45 Q8N2S8 G3XA82 Q6ZMZ0 Q5TH44
|
| Accessions |
CAF85699 EAX07489 EAX07490 EAX07491 Q6ZMZ0 AA194237 AK074486 BAC11017 AK131439 BAD18585 BC020595 AAH20595 BC062374 AAH62374 BC113560 AAI13561 BC143687 AAI43688 DA630289 XM_006710356 XP_006710419 XM_006710357 XP_006710420 XM_006710358 XP_006710421 NM_001127361 NP_001120833 NM_001300826 NP_001287755 NM_153341 NP_699172
|
| Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. {ECO:0000269|PubMed:10438909, ECO:0000269|PubMed:16709802}.
|
| Subcellular Location |
Cytoplasmic granule membrane {ECO:0000269|PubMed:10438909}; Multi-pass membrane protein {ECO:0000269|PubMed:10438909}.
|
| Tissue Specificity |
Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells (at protein level). {ECO:0000269|PubMed:10438909, ECO:0000269|PubMed:10912506}.
|