Gene Symbol | SNRNP70 |
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Entrez Gene | 6625 |
Alt Symbol | RNPU1Z, RPU1, SNRP70, Snp1, U1-70K, U170K, U1AP, U1RNP |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein 70kDa (U1) |
Other Description | U1 small nuclear ribonucleoprotein 70 kDa|U1 snRNP 70 kDa |
Swissprots | B3KUA3 Q15687 P78494 Q9UE48 Q9UE47 Q15364 Q9UE45 P08621 P78493 Q9UFQ6 Q15689 Q99377 Q9UE46 Q15686 |
Accessions | AAA36571 AAA36572 AAA36573 EAW52445 EAW52446 EAW52447 EAW52448 EAW52449 EAW52450 EAW52451 EAW52452 EAW52453 P08621 AK027127 AK056808 BAG51812 AK096783 BAG53365 AK293120 BAF85809 AL117399 CAB55900 AL117507 CAB55969 AL560281 AL832819 BC000342 AAH00342 BC001315 AAH01315 BE397125 BM969999 CN292681 DA403443 DB031937 DB189176 M22636 AAA03001 X06811 CAA29960 X06812 CAA29961 X06813 CAA29962 X06814 CAA29963 X06815 CAA29964 X06816 CAA29965 X06817 CAA29966 X06818 CAA29967 X06819 X07401 CAA30303 X07402 CAA30304 X07403 CAA30305 X84841 CAA59278 XM_005259178 XP_005259235 XM_011527240 XP_011525542 XM_011527241 XP_011525543 NM_001009820 NM_001301069 NP_001287998 NM_003089 NP_003080 |
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA. |
Subcellular Location | Nucleus. Nucleus speckle {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250}. |
Top Pathways | Spliceosome |
U1 SnRNP 70 CRISPR/Cas9 KO Plasmid (h) - sc-401829 from Santa Cruz Biotechnology
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U1 SnRNP 70 HDR Plasmid (h) - sc-401829-HDR from Santa Cruz Biotechnology
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U1 SnRNP 70 Double Nickase Plasmid (h) - sc-401829-NIC from Santa Cruz Biotechnology
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U1 SnRNP 70 Double Nickase Plasmid (h2) - sc-401829-NIC-2 from Santa Cruz Biotechnology
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U1 SnRNP 70 CRISPR Activation Plasmid (h) - sc-401829-ACT from Santa Cruz Biotechnology
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U1 SnRNP 70 CRISPR Activation Plasmid (h2) - sc-401829-ACT-2 from Santa Cruz Biotechnology
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U1 SnRNP 70 Lentiviral Activation Particles (h) - sc-401829-LAC from Santa Cruz Biotechnology
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U1 SnRNP 70 Lentiviral Activation Particles (h2) - sc-401829-LAC-2 from Santa Cruz Biotechnology
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U1 snRNP 70 siRNA (h) - sc-36768 from Santa Cruz Biotechnology
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U1 snRNP 70 shRNA Plasmid (h) - sc-36768-SH from Santa Cruz Biotechnology
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U1 snRNP 70 shRNA (h) Lentiviral Particles - sc-36768-V from Santa Cruz Biotechnology
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SNRP70 RNAi - H00006625-R02 from Novus Biologicals
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MISSION® esiRNA - EHU141351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20264 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20264 from Sigma-Aldrich
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SNRNP70 siRNA (Human) - CRH4508 from Cohesion Biosciences
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SNRP70 RNAi - H00006625-R01 from Novus Biologicals
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SNRNP70 - MBS8200297 from MyBioSource
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shRNA set against Human SNRNP70 (NM_003089.4) - SHH414292 from Creative biogene
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shRNA set against Human SNRP70(NM_003089.4) - SHL021542 from Creative biogene
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SNRNP70 shRNA Plasmid (Human) - CHH4508 from Cohesion Biosciences
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SNRNP70 miRNA 3'UTR clone - MiUTR1H-09695 from Creative biogene
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