Gene Symbol | HTR3B |
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Entrez Gene | 9177 |
Alt Symbol | 5-HT3B |
Species | Human |
Gene Type | protein-coding |
Description | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic |
Other Description | 5-HT3-B|5-hydroxytryptamine 3 receptor B subunit|5-hydroxytryptamine receptor 3B|serotonin-gated ion channel subunit |
Swissprots | Q0VJC3 O95264 B0YJ23 |
Accessions | ACA06001 ACE96223 ACE96228 ACE96238 ACE96243 ACE96248 ACE96253 ACE96258 ACE96263 EAW67236 O95264 AF080582 AAD12242 AF169255 AAF03691 AK314268 BAG36930 AM293589 CAL25321 BC141515 AAI41516 XM_011543063 XP_011541365 XM_011543064 XP_011541366 XM_011543065 XP_011541367 XM_011543066 XP_011541368 NM_006028 NP_006019 |
Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269|PubMed:12867984}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:21138434}; Multi-pass membrane protein {ECO:0000269|PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. |
Tissue Specificity | Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:9950429}. |
SR-3B CRISPR/Cas9 KO Plasmid (h) - sc-411250 from Santa Cruz Biotechnology
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SR-3B HDR Plasmid (h) - sc-411250-HDR from Santa Cruz Biotechnology
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SR-3B Double Nickase Plasmid (h) - sc-411250-NIC from Santa Cruz Biotechnology
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SR-3B Double Nickase Plasmid (h2) - sc-411250-NIC-2 from Santa Cruz Biotechnology
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SR-3B CRISPR Activation Plasmid (h) - sc-411250-ACT from Santa Cruz Biotechnology
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SR-3B CRISPR Activation Plasmid (h2) - sc-411250-ACT-2 from Santa Cruz Biotechnology
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SR-3B Lentiviral Activation Particles (h) - sc-411250-LAC from Santa Cruz Biotechnology
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SR-3B Lentiviral Activation Particles (h2) - sc-411250-LAC-2 from Santa Cruz Biotechnology
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SR-3B siRNA (h) - sc-61612 from Santa Cruz Biotechnology
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SR-3B shRNA Plasmid (h) - sc-61612-SH from Santa Cruz Biotechnology
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SR-3B shRNA (h) Lentiviral Particles - sc-61612-V from Santa Cruz Biotechnology
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5-HT3B RNAi - H00009177-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2320 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2320 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03713 from Sigma-Aldrich
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HTR3B siRNA (Human) - CRH6072 from Cohesion Biosciences
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HTR3B - MBS8207653 from MyBioSource
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shRNA set against Human Htr3b (NM_006028.4) - SHH315961 from Creative biogene
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Human HTR3B siRNA - orb266574 from Biorbyt
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HTR3B shRNA Plasmid (Human) - CHH6072 from Cohesion Biosciences
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HTR3B miRNA 3'UTR clone - MiUTR4H-TG04364 from Creative biogene
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