| Gene Symbol |
SLIRP
|
| Entrez Gene |
81892
|
| Alt Symbol |
C14orf156, DC50, PD04872
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRA stem-loop interacting RNA binding protein
|
| Other Description |
SRA stem-loop-interacting RNA-binding protein, mitochondrial
|
| Swissprots |
J3KMY7 Q9GZT3
|
| Accessions |
EAW81303 EAW81304 Q9GZT3 AF253980 AAG44629 AF271779 AAG44790 AJ272055 CAC81241 AY860853 AAX58600 BC017895 AAH17895 BM685909 BP289922 BQ083727 BU944910 BU955571 BU960115 EL951262 HQ257938 ADR82692 NM_001267863 NP_001254792 NM_001267864 NP_001254793 NM_031210 NP_112487 NR_052025
|
| Function |
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269|PubMed:16762838}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:16762838}. Nucleus {ECO:0000269|PubMed:16762838}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
|
| Tissue Specificity |
Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. {ECO:0000269|PubMed:16762838}.
|
![Western Blot: SLIRP Overexpression Lysate (Adult Normal) [NBL1-08181] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLIRP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8004_SLIRP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08181-img0002.jpg)