Gene Symbol | SLIRP |
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Entrez Gene | 81892 |
Alt Symbol | C14orf156, DC50, PD04872 |
Species | Human |
Gene Type | protein-coding |
Description | SRA stem-loop interacting RNA binding protein |
Other Description | SRA stem-loop-interacting RNA-binding protein, mitochondrial |
Swissprots | J3KMY7 Q9GZT3 |
Accessions | EAW81303 EAW81304 Q9GZT3 AF253980 AAG44629 AF271779 AAG44790 AJ272055 CAC81241 AY860853 AAX58600 BC017895 AAH17895 BM685909 BP289922 BQ083727 BU944910 BU955571 BU960115 EL951262 HQ257938 ADR82692 NM_001267863 NP_001254792 NM_001267864 NP_001254793 NM_031210 NP_112487 NR_052025 |
Function | RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269|PubMed:16762838}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:16762838}. Nucleus {ECO:0000269|PubMed:16762838}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters. |
Tissue Specificity | Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis. {ECO:0000269|PubMed:16762838}. |
SLIRP CRISPR/Cas9 KO Plasmid (h) - sc-418350 from Santa Cruz Biotechnology
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SLIRP HDR Plasmid (h) - sc-418350-HDR from Santa Cruz Biotechnology
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SLIRP Double Nickase Plasmid (h) - sc-418350-NIC from Santa Cruz Biotechnology
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SLIRP Double Nickase Plasmid (h2) - sc-418350-NIC-2 from Santa Cruz Biotechnology
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SLIRP CRISPR Activation Plasmid (h) - sc-418350-ACT from Santa Cruz Biotechnology
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SLIRP CRISPR Activation Plasmid (h2) - sc-418350-ACT-2 from Santa Cruz Biotechnology
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SLIRP Lentiviral Activation Particles (h) - sc-418350-LAC from Santa Cruz Biotechnology
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SLIRP Lentiviral Activation Particles (h2) - sc-418350-LAC-2 from Santa Cruz Biotechnology
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SLIRP siRNA (h) - sc-92406 from Santa Cruz Biotechnology
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SLIRP shRNA Plasmid (h) - sc-92406-SH from Santa Cruz Biotechnology
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SLIRP shRNA (h) Lentiviral Particles - sc-92406-V from Santa Cruz Biotechnology
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SLIRP RNAi - H00081892-R01 from Novus Biologicals
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MISSION® esiRNA - EHU056661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4328 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4328 from Sigma-Aldrich
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SLIRP siRNA (Human) - CRJ3081 from Cohesion Biosciences
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SLIRP - MBS8216885 from MyBioSource
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shRNA set against Human Slirp (NM_031210.5) - SHH412676 from Creative biogene
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SLIRP shRNA Plasmid (Human) - CHJ3081 from Cohesion Biosciences
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SLIRP miRNA 3'UTR clone - MiUTR3H-11086 from Creative biogene
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