CDC14B

Gene Symbol CDC14B
Entrez Gene 8555
Alt Symbol CDC14B3, Cdc14B1, Cdc14B2, hCDC14B
Species Human
Gene Type protein-coding
Description cell division cycle 14B
Other Description CDC14 cell division cycle 14 homolog B|dual specificity protein phosphatase CDC14B
Swissprots O43183 Q5JU08 B1AL32 O60730 O60729 A8MQ20 A6N5X8 B1AL31
Accessions AAT70726 EAW92658 EAW92659 O60729 AF023158 AAB88293 AF064104 AAC16661 AF064105 AAC16662 AK126388 BAG54321 AK225361 BC050013 BC156666 AAI56667 DA943563 EF611343 ABR12627 XM_005252288 XP_005252345 XM_011519146 XP_011517448 XM_011519147 XP_011517449 XM_011519148 XP_011517450 XM_011519149 XP_011517451 XM_011519150 XP_011517452 XM_011519151 XP_011517453 XM_011519152 XP_011517454 XM_011519153 XP_011517455 XM_011519154 XP_011517456 XM_011519155 XP_011517457 XM_011519156 XP_011517458 XM_011519157 XP_011517459 XM_011519158 XP_011517460 XM_011519159 XP_011517461 XM_011519160 XP_011517462 XR_242602 XR_929864 XR_929865 XR_929866 XR_929867 XR_929868 NM_001077181 NP_001070649 NM_003671 NP_003662 NM_033331 NP_201588 NM_033332
Function Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
Top Pathways Cell cycle

Cdc14b Phosphatase (B-2) - sc-376461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc14b Phosphatase (B-2): sc-376461. Western blot analysis of Cdc14b Phosphatase expression in non-transfected: sc-117752 (A) and human Cdc14b Phosphatase transfected: sc-174435 (B) 293T whole cell lysates.

Cdc14b Phosphatase (G-8) - sc-374572 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cdc14b Phosphatase (G-8): sc-374572. Immuno-fluorescence staining of methanol-fixed HeLa cells showing nucleolar and cytoplasmic localization.

Cdc14b Phosphatase (H-64) - sc-292139 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Cdc14b Phosphatase (W-17) - sc-69462 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Cdc14B antibody - ab203675 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Mouse embryo tissue labeling Cdc14B with ab203675 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-Cdc14B antibody - ab167288 from Abcam

Host Mouse
Clonality Polyclonal
All lanes : Anti-Cdc14B antibody (ab167288) at 1 µg/mlLane 1 : Cdc14B transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-Cdc14B antibody - ab176022 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of 293 cells labeling Cdc14B with ab176022 at 1/10 (bottom histogram) compared to a negative control cell (top histogram). FITC conjugated Goat anti Rabbit secondary antibodies were used for the analysis.

Anti-Cdc14B antibody - ab104415 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Cdc14B antibody (ab104415) at 1 µg/ml + Human liver tissue lysate at 50 µg

Anti-CDC14B Antibody - LS-C309845 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CDC14B Antibody - LS-C309843 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDC14B Antibody - LS-C306855 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CDC14B Antibody (aa271-301) - LS-C168581 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of CDC14B Antibody in 293 cell line lysates (35 ug/lane). CDC14B (arrow) was detected using the purified antibody.

Cdc14B Antibody - H00008555-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Cdc14B Antibody [H00008555-A01] - Western Blot analysis of CDC14B expression in LNCaP.

Cdc14B Antibody - NBP1-84572 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cdc14B Antibody - H00008555-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Cdc14B Antibody - H00008555-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CDC14B Polyclonal Antibody - bs-7608R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti CDC14B Polyclonal Antibody, Unconjugated (bs-7608R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-CDC14B antibody produced in rabbit - HPA013312 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CDC14B: <B>Cat. No. HPA013312</B>: Immunohistochemical staining of human cerebellum shows strong nuclear membranous positivity in Purkinje cells.

Anti-CDC14B antibody produced in mouse - SAB1406684 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CDC14B: <B>Cat. No. SAB1406684</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-CDC14B antibody produced in rabbit - SAB1401431 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-CDC14B, antibody produced in rabbit, purified immunoglobulin: <B>Cat. No. SAB1401431</B>: Antibody concentration: 1.0 - 5.0 μg/mL. Specific band of ~56.8 kDa using human liver lysate.

CDC14B-Antibody-Center - AP9081c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of CDC14B Antibody (Center) (Cat. #AP9081c) in 293 cell line lysates (35ug/lane). CDC14B (arrow) was detected using the purified Pab.

CDC14B Antibody - middle region (OAAB05669) - OAAB05669 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

CDC14B antibody - GTX36294 from GeneTex

Prices $319.00
Sizes 50 μl
Host Rabbit
Clonality Polyclonal

CDC14B antibody, Internal - GTX80573 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-CDC14B antibody, Internal used in Flow cytometry/FACS. GTX80573

CDC14B Antibody (OABF01807) - OABF01807 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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