CDC14B

Gene Symbol CDC14B
Entrez Gene 8555
Alt Symbol CDC14B3, Cdc14B1, Cdc14B2, hCDC14B
Species Human
Gene Type protein-coding
Description cell division cycle 14B
Other Description CDC14 cell division cycle 14 homolog B|dual specificity protein phosphatase CDC14B
Swissprots O43183 Q5JU08 B1AL32 O60730 O60729 A8MQ20 A6N5X8 B1AL31
Accessions AAT70726 EAW92658 EAW92659 O60729 AF023158 AAB88293 AF064104 AAC16661 AF064105 AAC16662 AK126388 BAG54321 AK225361 BC050013 BC156666 AAI56667 DA943563 EF611343 ABR12627 XM_005252288 XP_005252345 XM_011519146 XP_011517448 XM_011519147 XP_011517449 XM_011519148 XP_011517450 XM_011519149 XP_011517451 XM_011519150 XP_011517452 XM_011519151 XP_011517453 XM_011519152 XP_011517454 XM_011519153 XP_011517455 XM_011519154 XP_011517456 XM_011519155 XP_011517457 XM_011519156 XP_011517458 XM_011519157 XP_011517459 XM_011519158 XP_011517460 XM_011519159 XP_011517461 XM_011519160 XP_011517462 XR_242602 XR_929864 XR_929865 XR_929866 XR_929867 XR_929868 NM_001077181 NP_001070649 NM_003671 NP_003662 NM_033331 NP_201588 NM_033332
Function Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.
Subcellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
Top Pathways Cell cycle

Human Cdc14B full length protein - ab160091 from Abcam

Category Protein
Prices $402.00
Sizes 2 µg
Source Wheat germ
Species Human
ab160091 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Human Cdc14B protein fragment - ab160092 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab160092 on a 12.5% SDS-PAGE stained with Coomassie Blue.

CDC14B Antibody Blocking Peptide - LS-E9930 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Cdc14B Protein - H00008555-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human Cdc14B Protein - H00008555-P01 from Novus Biologicals

Category Protein
Prices $319.00
Sizes 2 µg
Source Wheat Germ
Species Human

CDC14B-Antibody-Center-Blocking-Peptide - BP9081c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CDC14B - H00008555-P01 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Species Human

CDC14B - H00008555-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CDC14B - H00008555-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CDC14B fusion protein - ag18227 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

CDC14B fusion protein - ag18995 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

Recombinant Human Dual specificity protein phosphatase CDC14B(CDC14B) - CSB-YP004986HU CSB-EP004986HU CSB-BP004986HU CSB-MP004986HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Cdc14B Recombinant Protein Antigen - NBP1-84572PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CDC14B Peptide, Human - M34GP02791H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Dual specificity protein phosphatase CDC14B (CDC14B), Recombinant Protein - MBS1121339 from MyBioSource

Category Protein
Prices $1,285.00, $1,285.00, $1,505.00, $1,505.00, $2,110.00, $2,110.00, $2,570.00, $2,570.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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