| Gene Symbol |
CLDN15
|
| Entrez Gene |
24146
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
claudin 15
|
| Other Description |
claudin-15
|
| Swissprots |
B3KPB5 P56746
|
| Accessions |
EAW50210 EAW50211 P56746 AA514265 AJ245738 CAB52587 AK056103 BAG51627 AK124705 BC010160 AAH10160 DB158141 DN999248 JF432452 ADZ15669 NM_014343 NP_055158 NM_138429 NM_001185080 NP_001172009
|
| Function |
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853}.
|
| Subcellular Location |
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
|
| Tissue Specificity |
Detected in colon (at protein level). {ECO:0000269|PubMed:12055082}.
|
| Top Pathways |
Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C
|