CLDN15

Gene Symbol	CLDN15
Entrez Gene	24146
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	claudin 15
Other Description	claudin-15
Swissprots	B3KPB5 P56746
Accessions	EAW50210 EAW50211 P56746 AA514265 AJ245738 CAB52587 AK056103 BAG51627 AK124705 BC010160 AAH10160 DB158141 DN999248 JF432452 ADZ15669 NM_014343 NP_055158 NM_138429 NM_001185080 NP_001172009
Function	Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853}.
Subcellular Location	Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
Tissue Specificity	Detected in colon (at protein level). {ECO:0000269|PubMed:12055082}.
Top Pathways	Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Claudin 15 full length protein - ab161772 from Abcam Category Protein Source Wheat germ Species Human

CLDN15 / Claudin 15 Antibody Blocking Peptide - LS-E11899 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN15 / Claudin 15 Antibody Blocking Peptide - LS-E11898 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLDN15 / Claudin 15 Antibody Blocking Peptide - LS-E10342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Claudin-15 Recombinant Protein - H00024146-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

CLDN15-Antibody-Center-Blocking-Peptide - BP9831c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Claudin 15 Blocking Peptide - 33R-5429 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Claudin 15 Blocking Peptide - 33R-4831 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Claudin-15 / CLDN15 - H00024146-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

CLDN15 fusion protein - ag9437 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CLDN15 fusion protein - ag9124 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CLDN15 Peptide, Human - M34GP03228H from Creative Peptides Category Peptide Source Synthetic. Species Human

Claudin-15 (CLDN15), Recombinant Protein - MBS955281 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Claudin-15 (CLDN15), Recombinant Protein - MBS7011566 from MyBioSource Category Protein Prices $1,045.00, $2,030.00, $3,240.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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