CLDN15

Gene Symbol CLDN15
Entrez Gene 24146
Alt Symbol -
Species Human
Gene Type protein-coding
Description claudin 15
Other Description claudin-15
Swissprots B3KPB5 P56746
Accessions EAW50210 EAW50211 P56746 AA514265 AJ245738 CAB52587 AK056103 BAG51627 AK124705 BC010160 AAH10160 DB158141 DN999248 JF432452 ADZ15669 NM_014343 NP_055158 NM_138429 NM_001185080 NP_001172009
Function Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269|PubMed:12055082, ECO:0000269|PubMed:13129853}.
Subcellular Location Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.
Tissue Specificity Detected in colon (at protein level). {ECO:0000269|PubMed:12055082}.
Top Pathways Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C

claudin-15 CRISPR/Cas9 KO Plasmid (h) - sc-409860 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 HDR Plasmid (h) - sc-409860-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 Double Nickase Plasmid (h) - sc-409860-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 Double Nickase Plasmid (h2) - sc-409860-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 CRISPR Activation Plasmid (h) - sc-409860-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 CRISPR Activation Plasmid (h2) - sc-409860-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 Lentiviral Activation Particles (h) - sc-409860-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 Lentiviral Activation Particles (h2) - sc-409860-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

claudin-15 siRNA (h) - sc-43056 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

claudin-15 shRNA Plasmid (h) - sc-43056-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

claudin-15 shRNA (h) Lentiviral Particles - sc-43056-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU124961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6176 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6176 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLDN15 siRNA (Human) - CRH8474 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLDN15 - MBS8241168 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLDN15 (NM_014343.2) - SHH264681 from Creative biogene

Category siRNA
Species Reactivities Human

CLDN15 shRNA Plasmid (Human) - CHH8474 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLDN15 miRNA 3'UTR clone - MiUTR3H-14463 from Creative biogene

Species Reactivities Human
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