| Gene Symbol |
VKORC1L1
|
| Entrez Gene |
154807
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vitamin K epoxide reductase complex, subunit 1-like 1
|
| Other Description |
VKORC1-like protein 1|vitamin K epoxide reductase complex subunit 1-like protein 1
|
| Swissprots |
Q6AHW9 E7ETM5 B4E222 Q8N0U8 Q6TEK6
|
| Accessions |
EAX07952 Q8N0U8 AK000750 AK001747 AK055860 AK124688 AK289522 BAF82211 AK304077 BAG64984 AL137548 AY423045 AAR82915 BC007465 BC014249 BC027734 AAH27734 BM991935 BX647631 CR627471 CAH10673 DQ572761 HQ447784 ADQ32268 XM_011515830 XP_011514132 XM_011515831 XP_011514133 NM_001284342 NP_001271271 NM_173517 NP_775788
|
| Function |
Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}; Multi- pass membrane protein {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}.
|
| Top Pathways |
Ubiquinone and other terpenoid-quinone biosynthesis
|