Gene Symbol | VKORC1L1 |
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Entrez Gene | 154807 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | vitamin K epoxide reductase complex, subunit 1-like 1 |
Other Description | VKORC1-like protein 1|vitamin K epoxide reductase complex subunit 1-like protein 1 |
Swissprots | Q6AHW9 E7ETM5 B4E222 Q8N0U8 Q6TEK6 |
Accessions | EAX07952 Q8N0U8 AK000750 AK001747 AK055860 AK124688 AK289522 BAF82211 AK304077 BAG64984 AL137548 AY423045 AAR82915 BC007465 BC014249 BC027734 AAH27734 BM991935 BX647631 CR627471 CAH10673 DQ572761 HQ447784 ADQ32268 XM_011515830 XP_011514132 XM_011515831 XP_011514133 NM_001284342 NP_001271271 NM_173517 NP_775788 |
Function | Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:23928358, ECO:0000269|PubMed:24532791}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}; Multi- pass membrane protein {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}. |
Top Pathways | Ubiquinone and other terpenoid-quinone biosynthesis |
VKOR CRISPR/Cas9 KO Plasmid (h) - sc-407875 from Santa Cruz Biotechnology
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VKOR HDR Plasmid (h) - sc-407875-HDR from Santa Cruz Biotechnology
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VKOR Double Nickase Plasmid (h) - sc-407875-NIC from Santa Cruz Biotechnology
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VKOR Double Nickase Plasmid (h2) - sc-407875-NIC-2 from Santa Cruz Biotechnology
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VKOR CRISPR Activation Plasmid (h) - sc-407875-ACT from Santa Cruz Biotechnology
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VKOR CRISPR Activation Plasmid (h2) - sc-407875-ACT-2 from Santa Cruz Biotechnology
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VKOR Lentiviral Activation Particles (h) - sc-407875-LAC from Santa Cruz Biotechnology
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VKOR Lentiviral Activation Particles (h2) - sc-407875-LAC-2 from Santa Cruz Biotechnology
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VKORC1L1 siRNA (h) - sc-61792 from Santa Cruz Biotechnology
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VKORC1L1 shRNA Plasmid (h) - sc-61792-SH from Santa Cruz Biotechnology
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VKORC1L1 shRNA (h) Lentiviral Particles - sc-61792-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU040991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22690 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22690 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04735 from Sigma-Aldrich
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VKORC1L1 siRNA (Human) - CRJ5803 from Cohesion Biosciences
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VKORC1L1 - MBS8240140 from MyBioSource
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shRNA set against Human VKORC1L1 (NM_173517.3) - SHH442836 from Creative biogene
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shRNA set against Human VKORC1L1(NM_173517.3) - SHL126142 from Creative biogene
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VKORC1L1 shRNA Plasmid (Human) - CHJ5803 from Cohesion Biosciences
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VKORC1L1 miRNA 3'UTR clone - MiUTR1H-11124 from Creative biogene
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