RELB
| Gene Symbol | RELB |
|---|---|
| Entrez Gene | 5971 |
| Alt Symbol | I-REL, IREL, REL-B |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog B |
| Other Description | transcription factor RelB|v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)|v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 |
| Swissprots | Q6GTX7 Q9UEI7 Q01201 |
| Accessions | AAC82346 ABC40746 EAW57316 Q01201 AK290594 BAF83283 AL583128 AW137991 BC028013 AAH28013 BI906507 BM684710 DA940587 M83221 AAA36127 XM_005259127 XP_005259184 XM_005259128 XP_005259185 NM_006509 NP_006500 |
| Function | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa- |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the centrosome. |
| Top Pathways | MAPK signaling pathway, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection |
RelB CRISPR/Cas9 KO Plasmid (h) - sc-400371 from Santa Cruz Biotechnology
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RelB HDR Plasmid (h) - sc-400371-HDR from Santa Cruz Biotechnology
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RelB Double Nickase Plasmid (h) - sc-400371-NIC from Santa Cruz Biotechnology
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RelB Double Nickase Plasmid (h2) - sc-400371-NIC-2 from Santa Cruz Biotechnology
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RelB CRISPR Activation Plasmid (h) - sc-400371-ACT from Santa Cruz Biotechnology
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RelB CRISPR Activation Plasmid (h2) - sc-400371-ACT-2 from Santa Cruz Biotechnology
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RelB Lentiviral Activation Particles (h) - sc-400371-LAC from Santa Cruz Biotechnology
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RelB Lentiviral Activation Particles (h2) - sc-400371-LAC-2 from Santa Cruz Biotechnology
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RelB siRNA (h) - sc-36402 from Santa Cruz Biotechnology
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RelB shRNA Plasmid (h) - sc-36402-SH from Santa Cruz Biotechnology
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RelB shRNA (h) Lentiviral Particles - sc-36402-V from Santa Cruz Biotechnology
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RelB RNAi - H00005971-R01 from Novus Biologicals
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MISSION® esiRNA - EHU137171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1390 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1390 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03745 from Sigma-Aldrich
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RELB siRNA (Human) - CRH4041 from Cohesion Biosciences
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RELB - MBS8221454 from MyBioSource
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RelB CRISPR/Cas9 KO Plasmid (h2) - sc-400371-KO-2 from Santa Cruz Biotechnology
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RelB HDR Plasmid (h2) - sc-400371-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human RELB (NM_006509.3) - SHH391812 from Creative biogene
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Human RELB siRNA - orb264543 from Biorbyt
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RELB shRNA Plasmid (Human) - CHH4041 from Cohesion Biosciences
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