AMICA1
| Gene Symbol | AMICA1 |
|---|---|
| Entrez Gene | 120425 |
| Alt Symbol | AMICA, CREA7-1, CREA7-4, Gm638, JAML |
| Species | Human |
| Gene Type | protein-coding |
| Description | adhesion molecule, interacts with CXADR antigen 1 |
| Other Description | adhesion molecule AMICA|adhesion molecule interacting with CXADR antigen 1|dendritic-cell specific protein CREA7-1|dendritic-cell specific protein CREA7-4|junctional adhesion molecule-like |
| Swissprots | Q8NF70 Q5DTC6 B0YIV1 Q8N9I7 B0YIV2 Q7Z499 Q496M1 Q86YT9 |
| Accessions | ACA05929 ACA05930 CCF77025 CCF77026 EAW67354 EAW67355 Q86YT9 AJ515553 CAD56620 AK057590 AK090409 BAC03390 AK094399 BAC04347 AK097285 BAG53445 AK298722 BAG60876 AK300851 BAG62502 AK301099 BAG62698 AW804077 AY093686 AAM15730 AY093687 AAM15731 AY138965 AAN52117 AY358362 AAQ88728 BC100794 AAI00795 BC100795 AAI00796 BC100796 AAI00797 BC100797 AAI00798 DA090367 DC296115 XM_005271407 XP_005271464 XM_011542606 XP_011540908 XM_011542607 XP_011540909 NM_001098526 NP_001091996 NM_001286570 NP_001273499 NM_001286571 NP_001273500 NM_153206 NP_694938 NR_104479 |
| Function | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. |
| Tissue Specificity | Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}. |
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