AMICA1

Gene Symbol	AMICA1
Entrez Gene	120425
Alt Symbol	AMICA, CREA7-1, CREA7-4, Gm638, JAML
Species	Human
Gene Type	protein-coding
Description	adhesion molecule, interacts with CXADR antigen 1
Other Description	adhesion molecule AMICA|adhesion molecule interacting with CXADR antigen 1|dendritic-cell specific protein CREA7-1|dendritic-cell specific protein CREA7-4|junctional adhesion molecule-like
Swissprots	Q8NF70 Q5DTC6 B0YIV1 Q8N9I7 B0YIV2 Q7Z499 Q496M1 Q86YT9
Accessions	ACA05929 ACA05930 CCF77025 CCF77026 EAW67354 EAW67355 Q86YT9 AJ515553 CAD56620 AK057590 AK090409 BAC03390 AK094399 BAC04347 AK097285 BAG53445 AK298722 BAG60876 AK300851 BAG62502 AK301099 BAG62698 AW804077 AY093686 AAM15730 AY093687 AAM15731 AY138965 AAN52117 AY358362 AAQ88728 BC100794 AAI00795 BC100795 AAI00796 BC100796 AAI00797 BC100797 AAI00798 DA090367 DC296115 XM_005271407 XP_005271464 XM_011542606 XP_011540908 XM_011542607 XP_011540909 NM_001098526 NP_001091996 NM_001286570 NP_001273499 NM_001286571 NP_001273500 NM_153206 NP_694938 NR_104479
Function	Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts.
Tissue Specificity	Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human JAML protein fragment - ab132671 from Abcam Category Protein Source Wheat germ Species Human

JAML protein (His-DHFR tag) - ab127608 from Abcam Category Protein Source E. coli Species Human

AMICA / JAML Antibody Blocking Peptide - LS-E5045 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AMICA / JAML Antibody Blocking Peptide - LS-E24396 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AMICA/JAML Recombinant Protein - H00120425-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

AMICA1-Antibody-N-term-Blocking-Peptide - BP17456a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human AMICA Fc Chimera, CF - 3449-AM-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human adhesion molecule AMICA protein - orb83374 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Species Human

AMICA1 / JAML - H00120425-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

AMICA1 / JAML - H00120425-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

AMICA1 fusion protein - ag16763 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

AMICA1 fusion protein - ag15900 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human AMICA1, His tagged - AMICA1-2262H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human AMICA1 - AMICA1-954H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human AMICA1, Fc Chimera - AMICA1-839H from Creative Biomart Category Protein Source NSO Cells Species Human

JAML - PN201752 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Human JAML / AMICA Protein (His Tag) - 10120-H08H-50 from Sino Biological Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Recombinant Human Junctional adhesion molecule-like(AMICA1) - CSB-YP774838HU CSB-EP774838HU CSB-BP774838HU CSB-MP774838HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human AMICA Fc Chimera Protein, CF - 3449-AM from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Human AMICA (Leu10 - Leu265) Accession # NP_694938 IEGRMD Human IgG 1 (Pro100 - Lys330) N-terminus C-terminus Species Human

AMICA1 / JAML (transcript variant 1) - TP318818 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human JAML / AMICA Protein (His tag) - PKSH031859 from Elabscience Category Protein Source Human Cell Species Human

AMICA/JAML Recombinant Protein Antigen - NBP2-14286PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

AMICA1 Peptide, Human - M34GP00555H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human JAML / AMICA Protein (His Tag) - 10120-H08H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

JAML / AMICA, Recombinant Protein - MBS2546511 from MyBioSource Category Protein Prices $475.00, $775.00 Sizes 50 µg, 100 µg Source Human Cells

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