| Gene Symbol |
UNC45A
|
| Entrez Gene |
55898
|
| Alt Symbol |
GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-45 homolog A (C. elegans)
|
| Other Description |
general cell UNC45|protein unc-45 homolog A|smooth muscle cell associated protein-1
|
| Swissprots |
Q9NSE8 Q9NSE9 A8K6F7 Q9H3U8 Q7L3Y6 Q9H3U1
|
| Accessions |
EAX02127 EAX02128 EAX02129 Q9H3U1 AB014729 BAB20266 AB014736 BAB20273 AK000905 BAA91418 AK125523 AK125721 BAG54239 AK291622 BAF84311 AK293538 BAG57020 AK296964 BAG59508 AK302979 BAG64122 AL357532 AL357537 CAB93428 AL357538 CAB93429 BC006214 AAH06214 BC010995 AAH10995 BC037992 AAH37992 BC045635 AAH45635 DQ892953 ABM83879 DQ896200 ABM87199 XM_005254963 XP_005255020 XM_011521779 XP_011520081 XM_011521780 XP_011520082 NM_017979 NM_001039675 NP_001034764 NM_018671 NP_061141
|
| Function |
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000305}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16478993}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16478993}. Nucleus {ECO:0000269|PubMed:16478993}. Note=Predominant in the perinuclear region. Little protein in the nucleus.
|
| Tissue Specificity |
Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. {ECO:0000269|PubMed:12119110}.
|