Gene Symbol | UNC45A |
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Entrez Gene | 55898 |
Alt Symbol | GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A |
Species | Human |
Gene Type | protein-coding |
Description | unc-45 homolog A (C. elegans) |
Other Description | general cell UNC45|protein unc-45 homolog A|smooth muscle cell associated protein-1 |
Swissprots | Q9NSE8 Q9NSE9 A8K6F7 Q9H3U8 Q7L3Y6 Q9H3U1 |
Accessions | EAX02127 EAX02128 EAX02129 Q9H3U1 AB014729 BAB20266 AB014736 BAB20273 AK000905 BAA91418 AK125523 AK125721 BAG54239 AK291622 BAF84311 AK293538 BAG57020 AK296964 BAG59508 AK302979 BAG64122 AL357532 AL357537 CAB93428 AL357538 CAB93429 BC006214 AAH06214 BC010995 AAH10995 BC037992 AAH37992 BC045635 AAH45635 DQ892953 ABM83879 DQ896200 ABM87199 XM_005254963 XP_005255020 XM_011521779 XP_011520081 XM_011521780 XP_011520082 NM_017979 NM_001039675 NP_001034764 NM_018671 NP_061141 |
Function | Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). {ECO:0000250, ECO:0000305}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16478993}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16478993}. Nucleus {ECO:0000269|PubMed:16478993}. Note=Predominant in the perinuclear region. Little protein in the nucleus. |
Tissue Specificity | Detected in peripheral blood leukocytes, bone marrow, adrenal gland, trachea, spinal cord, thyroid, lymph node and stomach. {ECO:0000269|PubMed:12119110}. |
Human UNC45A full length protein - ab163268 from Abcam
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SMAP1 Antibody Blocking Peptide - LS-E6226 from LifeSpan Bioscience
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SMAP1 Antibody Blocking Peptide - LS-E20407 from LifeSpan Bioscience
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SMAP1 Antibody Blocking Peptide - LS-E20408 from LifeSpan Bioscience
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UNC45A Antibody Blocking Peptide - LS-E1976 from LifeSpan Bioscience
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UNC45A Antibody Blocking Peptide - LS-E20395 from LifeSpan Bioscience
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UNC45A Antibody Blocking Peptide - LS-E20396 from LifeSpan Bioscience
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Recombinant Human SMAP1 Protein - H00060682-P01 from Novus Biologicals
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Recombinant Human UNC45A Protein - H00055898-P01 from Novus Biologicals
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UNC45A-Antibody-N-term-Blocking-peptide - BP12832a from Abgent, a WuXi AppTec company
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SMAP1 Blocking Peptide - 33R-4347 from Fitzgerald
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UNC45A Blocking Peptide - 33R-7872 from Fitzgerald
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UNC45A Blocking Peptide - 33R-7590 from Fitzgerald
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UNC45A - H00055898-P01 from Acris Antibodies
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UNC45A fusion protein - Ag7855 from Proteintech Group
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UNC45A fusion protein - Ag7790 from Proteintech Group
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Recombinant Human UNC45A, His-tagged - UNC45A-3597H from Creative Biomart
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Recombinant Human Protein unc-45 homolog A(UNC45A) ,partial - CSB-YP867145HU CSB-EP867145HU CSB-BP867145HU CSB-MP867145HU from Cusabio
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UNC45A (transcript variant 3) - TP306953 from Acris Antibodies
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UNC45A Recombinant Protein Antigen - NBP2-13506PEP from Novus Biologicals
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SMAP1 Recombinant Protein Antigen - NBP1-83702PEP from Novus Biologicals
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SMAP1 Peptide, Human - M34GP14720H from Creative Peptides
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UNC45A Peptide, Human - M34GP17088H from Creative Peptides
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Protein unc-45 homolog A (UNC45A), partial, Recombinant Protein - MBS1423104 from MyBioSource
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