OCRL

Gene Symbol OCRL
Entrez Gene 4952
Alt Symbol INPP5F, LOCR, NPHL2, OCRL-1, OCRL1
Species Human
Gene Type protein-coding
Description oculocerebrorenal syndrome of Lowe
Other Description Lowe oculocerebrorenal syndrome protein|inositol polyphosphate 5-phosphatase OCRL-1|phosphatidylinositol polyphosphate 5-phosphatase
Swissprots Q5JQF2 Q4VY09 Q15684 A6NKI1 Q15774 Q9UJG5 Q5JQF1 Q01968 B7ZLX2 Q4VY10 O60800 A8KAP2 Q9UMA5
Accessions EAX11830 EAX11831 EAX11832 Q01968 AK226116 AK293107 BAF85796 BC018003 AAH18003 BC025253 AAH25253 BC094726 AAH94726 BC130612 AAI30613 BC144106 AAI44107 S62084 AAD13933 S62085 AAB26926 U57627 AAB03839 XM_005262422 XP_005262479 XM_011531342 XP_011529644 XM_011531343 XP_011529645 XM_011531344 XP_011529646 XM_011531345 XP_011529647 XM_011531346 XP_011529648 NM_000276 NP_000267 NM_001587 NP_001578
Function Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly. {ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976}.
Subcellular Location Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Early endosome membrane. Membrane, clathrin-coated pit. Cell projection, cilium, photoreceptor outer segment. Cytoplasmic vesicle {ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Also found on macropinosomes.
Tissue Specificity Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. {ECO:0000269|PubMed:22543976}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

OCRL1 Antibody - 8797 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from ACHN and COS-7 cells using OCRL1 Antibody.

OCRL (C-2) - sc-393577 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
OCRL (C-2): sc-393577. Western blot analysis of OCRL expression in IMR-32 (A) and A-431 (B) whole cell lysates and HeLa nuclear extract (C).

OCRL (G-15) - sc-12088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OCRL (H-240) - sc-367989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
OCRL (H-240): sc-367989. Western blot analysis of OCRL expression in SH-SY5Y (A) and PC-3 (B) whole cell lysates.

OCRL (N-16) - sc-12087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OCRL (N-16): sc-12087. Western blot analysis of OCRL expression in KNRK whole cell lysate.

OCRL (P-16) - sc-12089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

OCRL (A-17) - sc-12090 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-INPP5F antibody - ab125917 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-INPP5F antibody (ab125917) at 1/500 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-INPP5F antibody - ab57988 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
INPP5F antibody (ab57988) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human kidney.

Anti-INPP5F antibody - ab90620 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-INPP5F antibody - ab135875 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-INPP5F antibody (ab135875) at 1/500 dilution + COLO205 cell lysate at 30 µg

Anti-INPP5F antibody [4A6] - ab124633 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4A6
ab124633, at 5 µg/mL, staining INPP5F in paraffin embedded Human kidney tissue by Immunohistochemistry.

Anti-INPP5F antibody [EP10256] - ab181039 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP10256
All lanes : Anti-INPP5F antibody [EP10256] (ab181039) at 1000 µgLane 1 : 293T cell lysatesLane 2 : SH-SY5Y cell lysatesLane 3 : HeLa cell lysatesLane 4 : JAR cell lysatesLysates/proteins at 10 µg per lane.

Anti-INPP5F antibody [S166A-26] (Biotin) - ab186240 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-INPP5F antibody [S166A-26] (FITC) - ab186304 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-INPP5F antibody [S166A-26] (HRP) - ab186316 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-INPP5F antibody [S166A26] - ab186326 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A26

Anti-OCRL Antibody (clone 4A6) IHC-plus™ - LS-B6106 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4A6
Anti-OCRL antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6106 concentration 5 ug/ml.

Anti-OCRL Antibody (aa940-954) - LS-C3148 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OCRL Antibody (aa40-56) - LS-C3147 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OCRL Antibody (N-Terminus) - LS-C153468 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-OCRL Antibody (aa1-901, clone S166A-26) - LS-C209552 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-OCRL Antibody (aa1-901, clone S166A-26, Atto 390) - LS-C229288 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-OCRL Antibody (aa1-901, clone S166A-26, Atto 488) - LS-C229289 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26

Anti-OCRL Antibody (aa1-901, clone S166A-26, Atto 565) - LS-C229290 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S166A-26
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