OCRL

Gene Symbol	OCRL
Entrez Gene	4952
Alt Symbol	INPP5F, LOCR, NPHL2, OCRL-1, OCRL1
Species	Human
Gene Type	protein-coding
Description	oculocerebrorenal syndrome of Lowe
Other Description	Lowe oculocerebrorenal syndrome protein|inositol polyphosphate 5-phosphatase OCRL-1|phosphatidylinositol polyphosphate 5-phosphatase
Swissprots	Q5JQF2 Q4VY09 Q15684 A6NKI1 Q15774 Q9UJG5 Q5JQF1 Q01968 B7ZLX2 Q4VY10 O60800 A8KAP2 Q9UMA5
Accessions	EAX11830 EAX11831 EAX11832 Q01968 AK226116 AK293107 BAF85796 BC018003 AAH18003 BC025253 AAH25253 BC094726 AAH94726 BC130612 AAI30613 BC144106 AAI44107 S62084 AAD13933 S62085 AAB26926 U57627 AAB03839 XM_005262422 XP_005262479 XM_011531342 XP_011529644 XM_011531343 XP_011529645 XM_011531344 XP_011529646 XM_011531345 XP_011529647 XM_011531346 XP_011529648 NM_000276 NP_000267 NM_001587 NP_001578
Function	Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly. {ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976}.
Subcellular Location	Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Early endosome membrane. Membrane, clathrin-coated pit. Cell projection, cilium, photoreceptor outer segment. Cytoplasmic vesicle {ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Also found on macropinosomes.
Tissue Specificity	Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. {ECO:0000269|PubMed:22543976}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OCRL 293T Cell Transient Overexpression Lysate(Denatured) - H00004952-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

OCRL overexpression lysate - LY400105 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

OCRL overexpression lysate - LY419853 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

OCRL overexpression lysate - LY429072 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

OCRL 293 Cell Lysate - 400192 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

OCRL Overexpression Lysate (Denatured) - H00004952-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

OCRL Overexpression Lysate (Native) - NBL1-13905 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

OCRL Overexpression Lysate (Native) - NBP2-08188 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

OCRL Over-expression Lysate Product - GWB-FB7F56 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

OCRL Overexpression Lysate (Native) - NBP2-09774 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human OCRL Knockdown Stable Cell Line - CSC-DC010804 from Creative biogene Category Cell Line Species Human

OCRL Knockout Cell Line-HEK293T - CSC-RT2020 from Creative biogene Category Cell Line Species Human

OCRL KO Cell Lysate-HEK293T - CLKO-1881 from Creative biogene Category Cell Lysate

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