OCRL

Gene Symbol	OCRL
Entrez Gene	4952
Alt Symbol	INPP5F, LOCR, NPHL2, OCRL-1, OCRL1
Species	Human
Gene Type	protein-coding
Description	oculocerebrorenal syndrome of Lowe
Other Description	Lowe oculocerebrorenal syndrome protein|inositol polyphosphate 5-phosphatase OCRL-1|phosphatidylinositol polyphosphate 5-phosphatase
Swissprots	Q5JQF2 Q4VY09 Q15684 A6NKI1 Q15774 Q9UJG5 Q5JQF1 Q01968 B7ZLX2 Q4VY10 O60800 A8KAP2 Q9UMA5
Accessions	EAX11830 EAX11831 EAX11832 Q01968 AK226116 AK293107 BAF85796 BC018003 AAH18003 BC025253 AAH25253 BC094726 AAH94726 BC130612 AAI30613 BC144106 AAI44107 S62084 AAD13933 S62085 AAB26926 U57627 AAB03839 XM_005262422 XP_005262479 XM_011531342 XP_011529644 XM_011531343 XP_011529645 XM_011531344 XP_011529646 XM_011531345 XP_011529647 XM_011531346 XP_011529648 NM_000276 NP_000267 NM_001587 NP_001578
Function	Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly. {ECO:0000269|PubMed:22228094, ECO:0000269|PubMed:22543976}.
Subcellular Location	Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Early endosome membrane. Membrane, clathrin-coated pit. Cell projection, cilium, photoreceptor outer segment. Cytoplasmic vesicle {ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Also found on macropinosomes.
Tissue Specificity	Brain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. {ECO:0000269|PubMed:22543976}.
Top Pathways	Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human INPP5F full length protein - ab159021 from Abcam Category Protein Source Wheat germ Species Human

Human INPP5F protein fragment - ab159022 from Abcam Category Protein Source Wheat germ Species Human

INPP5F Antibody Blocking Peptide - LS-E7567 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human OCRL Protein - H00004952-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human OCRL Protein - H00004952-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

OCRL Blocking Peptide - abx063031 from Abbexa Category Peptide Species Human, Monkey

OCRL - H00004952-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

OCRL - H00004952-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

OCRL - H00004952-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

OCRL - H00004952-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

OCRL fusion protein - Ag12282 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

OCRL fusion protein - Ag11900 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

OCRL1 Peptide - 350539 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human OCRL, His-tagged - OCRL-1442H from Creative Biomart Category Protein Source E.coli Species Human

OCRL Blocking Peptide - CBP1837 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

OCRL (Q199) Peptide - BS2951P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Inositol polyphosphate 5-phosphatase OCRL-1(OCRL) ,partial - CSB-YP016267HU CSB-EP016267HU CSB-BP016267HU CSB-MP016267HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

OCRL (transcript variant b) - TP310491 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

OCRL (transcript variant a) - TP320672 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

INPP5F Protein - NBP1-81693PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

OCRL Recombinant Protein Antigen - NBP1-80973PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

INPP5F Peptide, Human - M34GP07666H from Creative Peptides Category Peptide Source Synthetic. Species Human

OCRL Peptide, Human - M34GP10804H from Creative Peptides Category Peptide Source Synthetic. Species Human

Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), partial, Recombinant Protein - MBS718878 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

INPP5F fusion protein - Ag25687 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

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